Results 71 to 80 of about 50,034 (219)

GnRH Immunocontraception of Male and Female White-Tailed Deer Fawns

Human-Wildlife Interactions, 2017
Immunocontraceptive vaccines based on gonadotropin-releasing hormone (GnRH) have been tested in adult white-tailed deer (Odocoileus virginianus), but their effects on fawns are unknown.
Lowell A. Miller, James P. Gionfriddo, Jack C. Rhyan, Kathleen A. Fagerstone, Donald C. Wagner, Gary J. Killian   +5 more
doaj   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Tachykinin: recent developments and novel roles in health and disease

Biomolecular Concepts, 2014
Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides of the tachykinin (TK) family have been found and investigated.
Onaga Takenori
doaj   +1 more source

Precocious puberty in children - diagnosis, causes and treatment

Journal of Education, Health and Sport, 2019
Physiological sexual maturation begins with pulsatile gonadoliberin (GnRH) secretion by neurons in the arcuate hypothalamic nuclei. GnRH affects the synthesis and pulsatile secretion of the anterior pituitary gonadotropic hormones - LH and FSH, which ...
Adrianna Krupa, Ewa Piasek, Olga Padała, Maciej Putowski, Michał Konopelko   +4 more
doaj   +1 more source

Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate‐to‐Severe Endometriosis Pain: A Phase III, Multicentric, Double‐Blind, Active‐Controlled, Non‐Inferiority Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate‐to‐severe endometriosis‐associated pain. Design A multicentre, double‐blind, double‐dummy, randomised, parallel‐group, active‐controlled, non‐inferiority phase III study. Setting Nineteen clinical centres across India.
Sneha Bhoir, Jaldhara Patel, Tushar Palve, Mrinal Kanti Dash, Sweety Saigal, Gourisankar Kamilya, Shalini Srivastava, Kartikbhai Savalia, Tanusree Gupta, Deepa Choudhary, Manohar Rangaswamy, Vidya V Bhatt, Neena Gupta, Malathi Ponnuru, Parul Shah, Apurva Shetty, Shruti Saha, Reshma Quadros, Sucheta Pandit, Dipak Patil, Piyush Patel, Pravin Ghadge, Lalit Lakhwani, Suyog Mehta, Sadhana Joglekar   +24 more
wiley   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing, Xi Chen, Meiyan Jiang, Huiya Fang, Xiaoming Zhu, Xuejing Jin, Yonghui Jiao, Ningning Hou, Weiwei Gong, Aixia Liu   +9 more
wiley   +1 more source

Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose?

JCRPE, 2020
Objective:Doses of gonadotropin releasing hormone (GnRH) analogues used to treat idiopathic central precocious puberty (iCPP) vary among clinicians. Study aims were to evaluate the efficacy of a monthly 3.75 mg dose of leuprolide acetate (LA) to suppress
Doğuş Vurallı, Ayfer Alikaşifoğlu, İrem İyigün, Dicle Canoruç, Alev Ozon, Nazlı Gönç, Nurgün Kandemir   +6 more
doaj   +1 more source

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Outcomes for Patients With Micro‐Invasive or Small HER2+ Breast Cancer in Northern Sydney Local Health District

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This retrospective study of patients with small, node‐negative HER2+ breast cancer found favorable 5‐year invasive disease‐free survival rates—93% for pT1mic/a disease and 100% for pT1b disease. Trastuzumab was administered to 66% of patients and was associated with larger tumor size and higher histologic grade.
Yuanyuan Xue, Katrina Moore, Tricia Saurine, David Chan, Lina Pugliano, Connie Diakos   +5 more
wiley   +1 more source