Results 51 to 60 of about 108,821 (255)

Sperm DNA methylation profiling in patients with Kallmann syndrome

Endocrine Connections
Objective: This study aims to comprehensively characterize the DNA methylation profile in the sperm of patients with Kallmann syndrome (KS), providing new insights into the potential epigenetic mechanisms contributing to the pathogenesis of the disease ...
Rongrong Wang, Xiaogang Li, Jingdi Zhang, Xi Wang, Jiangfeng Mao, Xinxin Feng, Siyu Wang, Yongzhe Li, Xueyan Wu, Ye Guo   +9 more
doaj   +1 more source

Development of a GnRH Radioimmunoassay Utilizing a Superactive Synthetic GnRH Analog: D-[Lys6]-GnRH

Experimental Biology and Medicine, 1978
SummarySpecific, high titer anti-GnRH antisera were obtained following immunization of rabbits with a conjugate of thyroglobulin and D-[Lys6]-GnRH. D-[Lys6]-GnRH was chosen to take advantage of an ∊-amino group in the center of the peptide chain and three carbons away from the chain as a unique point of conjugation. The RIA developed with this antisera
D, Heber, W D, Odell
openaire   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages [PDF]

, 2013
Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors.
Daukss, Dana M., Decatur, Wayne A., Hall, Jeffrey A., Hayes, Mary K.   +3 more
core   +1 more source

On the selection and design of proteins and peptide derivatives for the production of photoluminescent, red-emitting gold quantum clusters [PDF]

, 2013
Novel pathways of the synthesis of photoluminescent gold quantum clusters (AuQCs) using biomolecules as reactants provide biocompatible products for biological imaging techniques.
A Baksi, A Harriman, A Retnakumari, AM Smith, BĐ Glišić, BĐ Glišić, C Giulivi, CAJ Lin, CAJ Lin, CF Shaw III, CL Liu, CV Durgadas, D Toroz, DM Chevrier, F Wen, G Mező, GA Simms, GS Harms, H Kawasaki, H Kawasaki, H Schmidbaur, H Tsunoyama, H Wei, J Xie, J Xie, JS Mohanty, K Chaudhari, L Shang, L Shang, M Zhu, MAH Muhammed, MAH Muhammed, MS Devadas, PK Xavier, PL Xavier, R Hamouda, S Link, S Si, TH Chen, X Wen, X Yuan, X Yuan, XL Guével, Y Negishi, Y Shichibu, Y Shichibu, Y Wang, YH Lin, YN Tan   +48 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Anorexia nervosa and reproduction: connecting brain to gonads [PDF]

, 2020
Anorexia nervosa (AN) is a psychiatric disorder that predominantly affects young women and is characterized by low caloric intake and a major dissatisfaction with one’s body image.
Ciobanu, Corina, Fica, Simona, Poterasu, Mihaela, Rowland, David L.   +3 more
core   +2 more sources