Results 21 to 30 of about 210,635 (269)

GnRH antagonists in IVF

Reproductive BioMedicine Online, 2005
The present review summarizes existing knowledge on the use of gonadotropin releasing hormone (GnRH) antagonists based on experience gathered after the completion of phase III comparative trials with GnRH agonists. Available data suggest that prolongation of the follicular phase significantly decreases the probability of pregnancy.
Kolibianakis, Efstratios, Tarlatzis, Basil, Devroey, Paul   +2 more
openaire   +3 more sources

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist. [PDF]

Pharmacol Res Perspect
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Wang Y, Zhao J, Zou F, Jiang W, Zhang J, Yu P, Ye L, Sun X, Li C, Tian J.   +9 more
europepmc   +2 more sources

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines [PDF]

, 2011
Breakthrough Breast CancerBackground: Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells.
Sims Andrew H, Faratian Dana, Miller, Nicola, Sims, Andrew H., Morgan, Kevin, Miller Nicola, Millar, Robert P., Langdon, Simon P., Ilgin Cagnan, Sims, Andrew, Dana Faratian, Robert P Millar, Meyer, Colette, Simon P Langdon, Colette Meyer, Harrison David J, Cagnan, Ilgin, Nicola Miller, Morgan Kevin, Millar Robert P, David J Harrison, Faratian, Dana, Langdon Simon P, Kevin Morgan, Meyer Colette, Cagnan Ilgin, Andrew H Sims, Harrison, David J., Harrison, David J.; id_orcid   +28 more
core   +2 more sources

Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study

Gynecology Obstetrics & Reproductive Medicine, 2021
OBJECTIVE: To compare some cycle characteristics and outcomes using a protocol consisting of a GnRH agonist trigger or hCG trigger after cotreatment with GnRH antagonist. STUDY DESIGN: Thirty-three patients under 35 years of age with polycystic ovarian
Gulay Beydilli Nacak, Elif Tozkir, Enis Ozkaya, Ebru Cogendez, Fatih Kaya   +4 more
doaj   +1 more source

Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor [PDF]

, 2008
Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
core   +1 more source

Comparison of the Cumulative Live Birth Rates of Progestin-Primed Ovarian Stimulation and Flexible GnRH Antagonist Protocols in Patients With Low Prognosis

Frontiers in Endocrinology, 2021
ObjectiveTo compare the cumulative live birth rate (CLBR) of the progestin-primed ovarian stimulation (PPOS) protocol with that of the flexible GnRH antagonist protocol in patients with poor prognosis diagnosed per the POSEIDON criteria.MethodsThis was a
Mingze Du, Junwei Zhang, Zhen Li, Xinmi Liu, Jing Li, Wenxia Liu, Yichun Guan   +6 more
doaj   +1 more source

Cloning and characterisation of gonadotropin-releasing hormone (GnRH) receptors in the cichlid (Haplochromis burtoni) and the zebrafish (Danio rerio) [PDF]

, 2003
Bibliography: leaves 75-89.The identification of multiple forms of gonadotropin-releasing hormone (GnRH) in a single species is becoming a common occurrence.
Morley, Michelle Gaye
core   +1 more source

The effectiveness of an oral gonadotropin-releasing hormone antagonist relugolix for retained products of conception (RPOC) formed after abortion at less than 22 weeks of gestation: a retrospective study

Frontiers in Medicine
PurposeThis study investigated the effectiveness of an oral GnRH antagonist for retained products of conception (RPOC) carrying a risk of heavy bleeding.MethodsWith IRB approval and patient consent, this retrospective study included 97 RPOC cases after ...
Satoko Sasatsu, Yosuke Ono, Dai Miyashita, Tatsuya Yoshihara, Kota Tanaka, So Owada, Kana Makino, Akiko Nakagomi, Maki Ogi, Eriko Ogasawara, Hikaru Tagaya, Hiroko Fukasawa, Yasuhiko Okuda, Osamu Yoshino   +13 more
doaj   +1 more source

Outcomes with and without GnRH antagonist administration.

, 2016
Outcomes with and without GnRH antagonist administration.
Shih-Chieh Huang (2622685), Shee-Uan Chen (149645), Hsing-Hua Lai (2622697), Yu-Wei Shih (2622700), Meng-Ju Lee (2622688), Huai-Ling Wang (2622691), Tzu-Hsuan Chuang (2622694)   +6 more
core   +1 more source

Impact of GnRH analogues on oocyte/embryo quality and embryo development in in vitro fertilization/intracytoplasmic sperm injection cycles: a case control study

Reproductive Biology and Endocrinology, 2009
Background Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF) being well analysed, the effect of analogues on oocyte/embryo quality and embryo development is still ...
Rigó János, Gilán Zsuzsa, Ledó Nóra, Fancsovits Péter, Murber Ákos, Urbancsek János   +5 more
doaj   +1 more source