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Kisspeptin and GnRH Pulse Generation
2013The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of GnRH release is essential to cause various reproductive events in both sexes, such as spermatogenesis, follicular development, and sex steroid synthesis.
Hiroaki, Okamura +5 more
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Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
Brain Research, 2010Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in mammalian species; the surge mode and the pulse mode. The surge mode, which is required for the induction of the preovulatory gonadotropin discharge in most species, is induced by the positive feedback of estrogen secreted by the mature ovarian follicle.
Kei-Ichiro, Maeda +6 more
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American Journal of Obstetrics and Gynecology, 1990
The notion of an oscillator or signal generator in the central nervous system that controls the rhythmic release of GnRH and, thereby, the pulsatile secretion of the gonadotropic hormones, originated in the finding of strikingly abrupt and rhythmic fluctuations in the concentration of LH in the plasma of ovariectomized monkeys. These oscillations had a
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The notion of an oscillator or signal generator in the central nervous system that controls the rhythmic release of GnRH and, thereby, the pulsatile secretion of the gonadotropic hormones, originated in the finding of strikingly abrupt and rhythmic fluctuations in the concentration of LH in the plasma of ovariectomized monkeys. These oscillations had a
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The electrophysiology of the GnRH pulse generator in the rhesus monkey
Journal of Steroid Biochemistry, 1989The electrophysiological correlates of hypothalamic GnRH pulse generator activity in the rhesus monkey are described. They are characterized by abrupt increases in neuronal multiunit electrical activity (volleys) that are coincident with the initiation of LH pulses in the peripheral circulation.
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Neuroendocrinology, 1997
The pulsatile secretion of luteinizing hormone (LH), occasioned by the pulsatile release of gonadotropin-releasing hormone (GnRH), is closely associated with concurrent increases in multiunit electrical activity in the mediobasal hypothalamus (MUA volleys), the electrophysiological correlates of GnRH pulse generator activity.
T, Ordög +5 more
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The pulsatile secretion of luteinizing hormone (LH), occasioned by the pulsatile release of gonadotropin-releasing hormone (GnRH), is closely associated with concurrent increases in multiunit electrical activity in the mediobasal hypothalamus (MUA volleys), the electrophysiological correlates of GnRH pulse generator activity.
T, Ordög +5 more
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Progesterone Regulation of the GnRH Pulse Generator
Kisspeptin neurons in the arcuate nucleus (ARN) represent the gonadotrophin- releasing hormone (GnRH) pulse generator responsible for driving the pulsatile release of GnRH and luteinising hormone (LH) secretion. In a healthy menstruating woman, following the mid-cycle ovulation, progesterone (P4) levels dramatically increase and exert a negative ...openaire +1 more source
Neuroendocrinology, 1992
Electrophysiological manifestation of the hypothalamic GnRH pulse generator activity was examined during the LH surge induced by estradiol in ovariectomized goats. The characteristic increases in the frequency of multiple unit activity (MUA volley) associated with the pulsatile secretion of LH were recorded using electrodes implanted bilaterally in the
T, Tanaka, Y, Mori, K, Hoshino
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Electrophysiological manifestation of the hypothalamic GnRH pulse generator activity was examined during the LH surge induced by estradiol in ovariectomized goats. The characteristic increases in the frequency of multiple unit activity (MUA volley) associated with the pulsatile secretion of LH were recorded using electrodes implanted bilaterally in the
T, Tanaka, Y, Mori, K, Hoshino
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Electrophysiological Analysis of GnRH Pulse Generator Activity in the Rhesus Monkey
1994Publisher Summary Many strategies have been used to monitor gonadotropin-releasing hormone (GnRH) pulse generator activity, in addition to the detection of luteinizing-hormone pulses in the peripheral blood. These have included the measurement of GnRH pulses in pituitary portal blood.
Kevin T. O'Byrne, Ernst Knobil
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Origins of the ‘KNDy hypothesis’ of GnRH pulse generation
Nature Reviews Endocrinology, 2022openaire +2 more sources