Results 91 to 100 of about 475,793 (348)

Should we use early less invasive hemodynamic monitoring in unstable ICU patients? [PDF]

, 2011
In the previous issue of Critical Care, Takala and colleagues presented the results of a multicenter study to investigate whether the early presence of less invasive hemodynamic monitoring improves outcome in patients admitted with hemodynamic ...
Bennett, D, Cecconi, M
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Contributions of the ventromedial prefrontal cortex to goal-directed action selection [PDF]

, 2011
In this article, it will be argued that one of the key contributions of the ventromedial prefrontal cortex (vmPFC) to goal-directed action selection lies both in retrieving the value of goals that are the putative outcomes of the decision process and in ...
O'Doherty, John P.
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A closer look at the effects of repeated cocaine exposure on adaptive decision making under conditions that promote goal-directed control

Frontiers in Psychiatry, 2016
It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection.
Briac eHalbout, Angela T Liu, Sean B Ostlund   +2 more
doaj   +1 more source

Goal-directed treatment of osteoporosis

Journal of Bone and Mineral Research, 2013
Abstract Drug treatment for osteoporosis typically begins with an oral bisphosphonate, regardless of initial bone mineral density (BMD) or fracture risk, and decisions to continue or change treatment are often based on evidence of response to treatment based on changes in BMD, bone turnover markers, and occurrence of fractures.
Steven R, Cummings, Felicia, Cosman, Richard, Eastell, Ian R, Reid, Mona, Mehta, E Michael, Lewiecki   +5 more
openaire   +2 more sources

eLife Assessment: Human Attention during Goal-directed Reading Comprehension Relies on Task Optimization

, 2023
Hang Zhang
openalex   +1 more source

Design of Organic Electronic Materials With a Goal-Directed Generative Model Powered by Deep Neural Networks and High-Throughput Molecular Simulations [PDF]

, 2022
H. Shaun Kwak, Yuling An, David J. Giesen, Thomas F. Hughes, Christopher T. Brown, Karl Leswing, Hadi Abroshan, Mathew D. Halls   +7 more
openalex   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

A Goal-Directed Implementation of Query Answering for Hybrid MKNF Knowledge Bases

, 2012
Ontologies and rules are usually loosely coupled in knowledge representation formalisms. In fact, ontologies use open-world reasoning while the leading semantics for rules use non-monotonic, closed-world reasoning.
ANA SOFIA GOMES, Baral, Drabent, Eiter, Gelfond, Hitzler, Horrocks, JOSÉ JÚLIO ALFERES, Knorr, Lifschitz, Lukacsy, Motik, Patel, Swift, TERRANCE SWIFT, van Gelder, Yang   +16 more
core   +1 more source