Results 71 to 80 of about 473,333 (297)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Goal-directed fluid therapy in major thoracoabdominal surgery [PDF]
Medicinski PodmladakGoal-directed fluid therapy (GDFT) in thoracic-abdominal surgery has proven to be very challenging for many years. Minimal-invasive hemodynamic monitoring has become the standard in Enhanced Recovery After Surgery (ERAS) protocols.
Đukanović Marija +2 more
doaj +1 more source
Evolution of the subcortical circuits controlling goal-directed behaviour [PDF]
, 2012 The aim of the work presented in this thesis was to reconstruct the minimal neural hardware that vertebrates use for goal-directed behaviour. By studying lamprey, one of the phylogenetically oldest vertebrates, we were able to identify the neural ...
Stephenson-Jones, Marcus
core +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Frontiers in Neuroscience, 2015 Because humans and animals encounter various situations, the ability to adaptively decide upon responses to any situation is essential. To date, however, decision processes and the underlying neural substrates have been investigated under specific ...
Akihiro eFunamizu +7 more
doaj +1 more source
Sex Differences in Spatial Accuracy Relate to the Neural Activation of Antagonistic Muscles in Young Adults [PDF]
, 2017 Sex is an important physiological variable of behavior, but its effect on motor control remains poorly understood. Some evidence suggests that women exhibit greater variability during constant contractions and poorer accuracy during goal-directed tasks ...
Casamento-Moran, Agostina +6 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The value of foresight: how prospection affects decision-making
Frontiers in Neuroscience, 2011 Traditional theories of decision-making assume that utilities are based on the intrinsic value of outcomes; in turn, these values depend on associations between expected outcomes and the current motivational state of the decision-maker.
Giovanni ePezzulo, Francesco eRigoli
doaj +1 more source
The Multiple Process Model of Goal-Directed Reaching Revisited [PDF]
, 2017 Recently our group forwarded a model of speed-accuracy relations in goal-directed reaching. A fundamental feature of our multiple process model was the distinction between two types of online regulation: impulse control and limb-target control.
Bennett, SJ +7 more
core +2 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source