Results 51 to 60 of about 473,333 (297)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Neuroimaging of Habit-based vs. Goal-directed behavior in Instrumental Learning [PDF]

, 2017
Addiction has been proposed to result from an overreliance on the habit-based and goal-directed controllers of behavior; however, few data exist to simultaneously support both behavioral and neuoranatomical aspects of this theory in humans.
Lawler, Michael Jacob
core   +1 more source

Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. [PDF]

, 2019
The transition from recreational drug use to addiction involves pathological learning processes that support a persistent shift from flexible, goal-directed to habit behavioral control.
Blurton-Jones, Matthew, Harvey, Eric, Kennedy, Pamela J   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Effect of hip CPM on gross motor function and development of the hip joint: a single-center randomized controlled study on spastic cerebral palsy children with hip dysplasia

Frontiers in Pediatrics, 2023
ObjectiveTo investigate the effectiveness of hip continuous passive motion (hCPM) on hip development at skeletal maturity and gross motor function for spastic cerebral palsy children with hip dysplasia.MethodsProspective case–control research of hCPM ...
Lulu Wang, Nuochen Zhang, Liwei Fang, Zhenzhen Cui, Huihui Niu, Fuli Lv, Dayong Hu, De Wu, De Wu   +8 more
doaj   +1 more source

Goal-Directed Planning for Habituated Agents by Active Inference Using a Variational Recurrent Neural Network [PDF]

, 2020
It is crucial to ask how agents can achieve goals by generating action plans using only partial models of the world acquired through habituated sensory-motor experiences.
Matsumoto, Takazumi, Tani, Jun
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Goal-directed vocal planning in a songbird

eLife
Songbirds’ vocal mastery is impressive, but to what extent is it a result of practice? Can they, based on experienced mismatch with a known target, plan the necessary changes to recover the target in a practice-free manner without intermittently singing?
Anja T Zai, Anna E Stepien, Nicolas Giret, Richard HR Hahnloser   +3 more
doaj   +1 more source

Premotor cortex is critical for goal-directed actions

Frontiers in Computational Neuroscience, 2013
Shifting between motor plans is often necessary for adaptive behavior. When faced with changing consequences of one’s actions, it is often imperative to switch from automatic actions to deliberative and controlled actions. The presupplementary motor area
Christina eGremel, Rui eCosta, Rui eCosta   +2 more
doaj   +1 more source