Results 61 to 70 of about 356,637 (266)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Goal-directed fluid therapy in the perioperative setting
Journal of Anaesthesiology Clinical Pharmacology, 2019 Improvement in patient outcomes has become a significant consideration with our limited resources in the surgical setting. The implementation of enhanced recovery pathway protocols has resulted in significant benefits to both the patients and hospitals ...
Julia B Kendrick +6 more
doaj +1 more source
A Unifying Approach to Goal-Directed Evaluation
BRICS Report Series, 2001 Goal-directed evaluation, as embodied in Icon and Snobol, is built on the notions of backtracking and of generating successive results, and therefore it has always been something of a challenge to specify and implement. In this article, we address this challenge using computational monads and partial evaluation.<br /> <br />We consider a ...
Olivier Danvy +2 more
openaire +5 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An Automata View to Goal-Directed Methods [PDF]
, 2017 Consequence-based and automata-based algorithms encompass two families of approaches that have been thoroughly studied as reasoning methods for many logical formalisms. While automata are useful for finding tight complexity bounds, consequence-based algorithms are typically simpler to describe, implement, and optimize.
Hutschenreiter, L, Peñaloza, R
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Goal-directed fluid therapy in major thoracoabdominal surgery [PDF]
Medicinski PodmladakGoal-directed fluid therapy (GDFT) in thoracic-abdominal surgery has proven to be very challenging for many years. Minimal-invasive hemodynamic monitoring has become the standard in Enhanced Recovery After Surgery (ERAS) protocols.
Đukanović Marija +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in Neuroscience, 2015 Because humans and animals encounter various situations, the ability to adaptively decide upon responses to any situation is essential. To date, however, decision processes and the underlying neural substrates have been investigated under specific ...
Akihiro eFunamizu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source