Results 61 to 70 of about 473,333 (297)

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

Frontiers in Systems Neuroscience, 2021
The ventral striatum, also called nucleus accumbens (NAc), has long been known to integrate information from cortical, thalamic, midbrain and limbic nuclei to mediate goal-directed behaviors.
Aurélie De Groote, Alban de Kerchove d’Exaerde   +1 more
doaj   +1 more source

Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery. [PDF]

, 2012
BACKGROUND: Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after ...
Abbas, Bellamy, Brandstrup, Brunkhorst, Bundgaard-Nielsen, Bundgaard-Nielsen, C. Challand, Davies, Dindo, Faiz, Futier, G. Minto, Gan, Giglio, Grocott, Hollowell, J.R. Sneyd, K.B. Hosie, Kehlet, Lees, Lobo, Mills, N. Mellor, Noblett, Older, P.D. Erasmus, Pearse, Powell-Tuck, R. Struthers, Roche, Sanders, Schortgen, Senagore, Shoemaker, Shoemaker, Snowden, Wakeling, Walsh, Wilson   +38 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Early Goal Directed Therapy: Do We Reach the End of Road?

Archives of Anesthesia and Critical Care, 2016
No ...
Ata Mahmoodpoor, Samad EJ Golzari
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Goal-directed behavior in Tenebrio molitor larvae

Scientific Reports
Can signs of intentional behavior be traced in an insect larva, traditionally thought to be driven only by mere reflexes? We trained Tenebrio molitor coleoptera larvae in a uniform Y-maze to prefer one target branch to get access to food, observing their
Andrea Dissegna, Massimo Turatto, Cinzia Chiandetti   +2 more
doaj   +1 more source

Goal-directed fluid therapy in the perioperative setting

Journal of Anaesthesiology Clinical Pharmacology, 2019
Improvement in patient outcomes has become a significant consideration with our limited resources in the surgical setting. The implementation of enhanced recovery pathway protocols has resulted in significant benefits to both the patients and hospitals ...
Julia B Kendrick, Alan David Kaye, Yiru Tong, Kumar Belani, Richard D Urman, Christopher Hoffman, Henry Liu   +6 more
doaj   +1 more source

Rule reactivation and capture errors in goal directed behaviour [PDF]

, 2017
In everyday life people may act automatically, following "unwanted" lines of action which are triggered by contextual cues and may interfere with current goals.
Duncan, J, Ferrari, J, García, M, González Gadea, ML, Ibáñez, A, Manes, F, Roca, M, Torralva, T, Torres Ardila, MJ   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Goal-directed therapy in osteoporosis [PDF]

Journal of Bone and Mineral Research, 2013
Themanagement of osteoporosis is changing—for the better. Perhaps the most progressive recent step has been the assessment of fracture risk using clinical risk factors through tools such as the Fracture Risk Assessment Tool (FRAX). In addition to traditional intervention thresholds, such as those for osteoporosis defined by the WHO T-score or prior ...
Eugene, McCloskey, William D, Leslie
openaire   +2 more sources