Results 81 to 90 of about 3,565,746 (293)
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
The value of foresight: how prospection affects decision-making
Frontiers in Neuroscience, 2011 Traditional theories of decision-making assume that utilities are based on the intrinsic value of outcomes; in turn, these values depend on associations between expected outcomes and the current motivational state of the decision-maker.
Giovanni ePezzulo, Francesco eRigoli
doaj +1 more source
A Unifying Approach to Goal-Directed Evaluation
BRICS Report Series, 2001 Goal-directed evaluation, as embodied in Icon and Snobol, is built on the notions of backtracking and of generating successive results, and therefore it has always been something of a challenge to specify and implement. In this article, we address this challenge using computational monads and partial evaluation.<br /> <br />We consider a ...
Olivier Danvy +2 more
openaire +6 more sources
An Automata View to Goal-Directed Methods [PDF]
, 2017 Consequence-based and automata-based algorithms encompass two families of approaches that have been thoroughly studied as reasoning methods for many logical formalisms. While automata are useful for finding tight complexity bounds, consequence-based algorithms are typically simpler to describe, implement, and optimize.
Hutschenreiter, L, Peñaloza, R
openaire +3 more sources
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Force dysmetria in spinocerebellar ataxia 6 correlates with functional capacity
Frontiers in Human Neuroscience, 2015 Spinocerebellar ataxia type 6 (SCA6) is a genetic disease that causes pure cerebellar degeneration affecting walking, balance, and coordination. One of the main symptoms of SCA6 is dysmetria.
Agostina eCasamento Moran +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
FEBS Open Bio, EarlyView.This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source
A nationwide student survey on biochemistry learning resources in Italy
FEBS Open Bio, EarlyView.We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti +4 more
wiley +1 more source
Parahippocampal neurons encode task-relevant information for goal-directed navigation
eLifeA behavioral strategy crucial to survival is directed navigation to a goal, such as a food or home location. One potential neural substrate for supporting goal-directed navigation is the parahippocampus, which contains neurons that represent an animal’s ...
Alexander Gonzalez, Lisa M Giocomo
doaj +1 more source