Evolution of the subcortical circuits controlling goal-directed behaviour [PDF]
, 2012 The aim of the work presented in this thesis was to reconstruct the minimal neural hardware that vertebrates use for goal-directed behaviour. By studying lamprey, one of the phylogenetically oldest vertebrates, we were able to identify the neural ...
Stephenson-Jones, Marcus
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Force dysmetria in spinocerebellar ataxia 6 correlates with functional capacity
Frontiers in Human Neuroscience, 2015 Spinocerebellar ataxia type 6 (SCA6) is a genetic disease that causes pure cerebellar degeneration affecting walking, balance, and coordination. One of the main symptoms of SCA6 is dysmetria.
Agostina eCasamento Moran +6 more
doaj +1 more source
Sex Differences in Spatial Accuracy Relate to the Neural Activation of Antagonistic Muscles in Young Adults [PDF]
, 2017 Sex is an important physiological variable of behavior, but its effect on motor control remains poorly understood. Some evidence suggests that women exhibit greater variability during constant contractions and poorer accuracy during goal-directed tasks ...
Casamento-Moran, Agostina +6 more
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
The Role of Hp-NCL Network in Goal-Directed Routing Information Encoding of Bird: A Review
Brain Sciences, 2020 Goal-directed navigation is a crucial behavior for the survival of animals, especially for the birds having extraordinary spatial navigation ability.
Mengmeng Li +4 more
doaj +1 more source
Supplemental Material for A Double-Blind Study Assessing the Impact of Orbitofrontal Theta Burst Stimulation on Goal-Directed Behavior [PDF]
, 2022 openalex +1 more source
The weight of emotions in decision-making: how fearful and happy facial stimuli modulate action readiness of goal-directed actions [PDF]
, 2018 Modern theories of behavioral control converge with the idea that goal-directed/voluntary behaviors are intimately tied to the evaluation of resources.
Mirabella, Giovanni
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Parahippocampal neurons encode task-relevant information for goal-directed navigation
eLifeA behavioral strategy crucial to survival is directed navigation to a goal, such as a food or home location. One potential neural substrate for supporting goal-directed navigation is the parahippocampus, which contains neurons that represent an animal’s ...
Alexander Gonzalez, Lisa M Giocomo
doaj +1 more source