Results 61 to 70 of about 7,767,661 (277)

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Additional file 4: of Targeting urine output and 30-day mortality in goal-directed therapy: a systematic review with meta-analysis and meta-regression [PDF]

, 2017
Figure S3. Forest plot of sensitivity analysis (urine output threshold 0.5 ml/kg/h) on 30-day mortality when comparing goal-directed therapy with conventional fluid management. +: mortality follow-up was shorter than 28 days.
Diederik Gommers (22889), Diederik Gommers, Mohamud Egal, Egal, M. (Mohamud), Groeneveld, A.B.J. (Johan), Esther N. van der Zee, Esther van der Zee (3741388), van der Zee, E.N. (Esther N.), A. Groeneveld (3741391), Mohamud Egal (3741385), Gommers, D.A.M.P.J. (Diederik), A. B. Johan Groeneveld   +11 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

Intraoperative fluid management in open gastrointestinal surgery: goal-directed versus restrictive

Clinics, 2012
OBJECTIVE: The optimal strategy for fluid management during gastrointestinal surgery remains unclear. Minimizing the variation in arterial pulse pressure, which is induced by mechanical ventilation, is a potential strategy to improve postoperative ...
Jun Zhang, Hui Qiao, Zhiyong He, Yun Wang, Xuehua Che, Weimin Liang   +5 more
doaj   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Goal-Directed Fluid Therapy in Sepsis and Septic Shock: A Review of Current Therapeutic Strategies and Outcomes

Journal of Education, Health and Sport
Introduction and purpose: Sepsis induces profound microvascular derangements, making prompt fluid resuscitation a management cornerstone. Historically guided by Early Goal-Directed Therapy (EGDT), landmark trials have refuted EGDT's rigidity, driving a ...
Maciej Dobrucki, Katarzyna Jolanta Kuc, Krzysztof Brzezicki, Katarzyna Zegadło, Mateusz Cieciora, Aleksandra Cieciora, Patryk Jakubiak, Małgorzata Kawiorska, Julia Surowiec, Wiktoria Ruta Bełcikowska-Skowron   +9 more
doaj   +1 more source

Effects of intraoperative goal-directed fluid therapy and restrictive fluid therapy combined with enhanced recovery after surgery protocol on complications after thoracoscopic lobectomy in high-risk patients: study protocol for a prospective randomized controlled trial

Trials, 2021
Background Acute kidney injury (AKI) is a common complication after thoracoscopic lobectomy in high-risk patients due to insufficient intraoperative infusion.
Zheng Guan, Yanfeng Gao, Qiao Qiao, Qiang Wang, Jingjie Liu   +4 more
doaj   +1 more source

Does Goal-directed Fluid Therapy Affect Postoperative Orthostatic Intolerance? [PDF]

Anesthesiology, 2013
Abstract Background: Early mobilization is important for postoperative recovery but is limited by orthostatic intolerance (OI) with a prevalence of 50% 6 h after major surgery. The pathophysiology of postoperative OI is assumed to include hypovolemia besides dysregulation of vasomotor tone ...
Bundgaard-Nielsen, Morten, Jans, Oivind, Müller, Rasmus Gamborg, Korshin, André Martin, Ruhnau, Birgitte, Bie, Peter, Secher, Niels H, Kehlet, Henrik   +7 more
openaire   +4 more sources