Results 51 to 60 of about 492,841 (300)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Goal-directed hemodynamic therapy in patients with colorectal cancer undergoing laparoscopic surgery

Вестник анестезиологии и реаниматологии, 2020
Introduction. The conductance of goal-directed hemodynamic therapy is controversial due to the difficulty in its implementation in routine practice despite the significant number of studies and meta-analyses.Objective.
V. A. Panafidina, I. V. Shlyk
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Goal-directed therapy in patients with early acute kidney injury: a multicenter randomized controlled trial

Clinics, 2018
OBJECTIVES: Acute kidney injury is associated with many conditions, and no interventions to improve the outcomes of established acute kidney injury have been developed.
Cristina Prata Amendola, João Manoel Silva-Jr, Taisa Carvalho, Luciana Coelho Sanches, Ulysses Vasconcelos de Andrade e Silva, Rosana Almeida, Emmanuel Burdmann, Emerson Lima, Fabiana Ferreira Barbosa, Renata Souza Ferreira, Maria José C. Carmona, Luiz Marcelo Sá Malbouisson, Fernando A.M. Nogueira, José Otavio Costa Auler-Júnior, Suzana Margareth Lobo   +14 more
doaj   +1 more source

Intra-Operative Fluid Management in Adult Neurosurgical Patients Undergoing Intracranial Tumour Surgery: Randomised Control Trial Comparing Pulse Pressure Variance (PPV) and Central Venous Pressure (CVP) [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Fluid management in neurosurgery presents specific challenges to the anaesthesiologist. Dynamic parameters like Pulse Pressure Variation (PPV) have been used successfully to guide fluid management.
Shalini Cynthia Sundaram, Serina Ruth Salins, Amar Nandha Kumar, Grace Korula   +3 more
doaj   +1 more source

The Negativity Bias Predicts Response Rate To Behavioral Activation For Depression [PDF]

, 2016
Background and Objectives: This treatment study investigated the extent to which asymmetric dimensions of affective responding, specifically the positivity offset and the negativity bias, at pretreatment altered the rate of response to Behavioral ...
Cacioppo, J., Gollan, J. K., Hoxha, D., Hunnicutt-Ferguson, K., Norris, Catherine, Rosebrock, L., Sankin, L.   +6 more
core   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Early Goal Directed Therapy: Do We Reach the End of Road?

Archives of Anesthesia and Critical Care, 2016
No ...
Ata Mahmoodpoor, Samad EJ Golzari
doaj  

A Review of Intraoperative Goal-Directed Therapy Using Arterial Waveform Analysis for Assessment of Cardiac Output

The Scientific World Journal, 2014
Increasing evidence shows that goal-directed hemodynamic management can improve outcomes in surgical and intensive care settings. Arterial waveform analysis is one of the different techniques used for guiding goal-directed therapy.
Neil Mehta, Ana Fernandez-Bustamante, Tamas Seres   +2 more
doaj   +1 more source

Goal-directed fluid optimization based on stroke volume variation and cardiac index during one-lung ventilation in patients undergoing thoracoscopy lobectomy operations: a pilot study

Clinics, 2013
OBJECTIVES: This pilot study was designed to utilize stroke volume variation and cardiac index to ensure fluid optimization during one-lung ventilation in patients undergoing thoracoscopic lobectomies.
Jian Zhang, Chao Qin Chen, Xiu Zhen Lei, Zhi Ying Feng, Sheng Mei Zhu   +4 more
doaj   +1 more source