Results 91 to 100 of about 5,377,289 (311)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Comprehensive assessment and analysis of urban resilience based on fusion modeling–taking guilin as an example

International Journal of Digital Earth
Dramatic global climate change has led to an increase in multiple and uncertain risks to urban safety and sustainable development, and cities urgently need to enhance their comprehensive response capacity.
Liduo Dou, Lanwei Zhu, Yuxin He, Meiqing Wu, Yifei Guo   +4 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Does organic farming achieve environmental goals efficiently? [PDF]

, 2002
Concerns about the impact of modern agriculture on the environment have in the past few decades resulted in strict legislation concerning the leaching of nitrogen from Danish farms and their use of pesticides.
Jacobsen, Lars-Bo
core  

Planetary Microlensing: Present Status and Long-term Goals

, 1999
Massive gravitational microlensing programs were begun about a decade ago as a means to search for compact baryonic dark matter in the Galaxy, but before the first events were detected the technique was also proposed as a means of detecting extra-solar ...
Sackett, Penny D.
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Goals of Education in the USA [PDF]

, 2008
The article deals with the main goals of education in the ...
Коваль, А. В.
core  

Improved indicators for the integrated assessment of coastal sustainable development based on Earth Observation Data

International Journal of Digital Earth
Target 14 of the Sustainable Development Goals (SDG 14) depicts a better future regarding the capacity of coastal environments to cope with several developmental challenges.
Li Zhang, Jian Zuo, Bowei Chen, Jingjuan Liao, Min Yan, Linyan Bai, Dewayany Sutrisno, Mazlan Hashim, M. M. Abdullah Al Mamun   +8 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Large-Scale nighttime illuminated road extraction in the BTH region of China using SDGSAT-1 nighttime light data

International Journal of Digital Earth
Nighttime illuminated roads (NTIRs) are closely related to residents' nighttime travel and activities. However, traditional nighttime light (NTL) data are not highly applicable for large-scale NTIR extraction tasks because of challenges such as low ...
Qiyuan Xie, Hui Li, Linhai Jing, Yichen Jiang, Haifeng Ding, Zhongchang Sun   +5 more
doaj   +1 more source