Results 81 to 90 of about 5,377,289 (311)

CURIOUS: Intrinsically Motivated Modular Multi-Goal Reinforcement Learning [PDF]

, 2019
In open-ended environments, autonomous learning agents must set their own goals and build their own curriculum through an intrinsically motivated exploration.
Chetouani, Mohamed, Colas, Cédric, Fournier, Pierre, Oudeyer, Pierre-Yves, Sigaud, Olivier   +4 more
core   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Optimizing future dark energy surveys for model selection goals [PDF]

, 2011
We demonstrate a methodology for optimizing the ability of future dark energy surveys to answer model selection questions, such as `Is acceleration due to a cosmological constant or a dynamical dark energy model?'.
Andrew R. Liddle, Bassett, Bassett, Bassett, Caldwell, Catherine Watkinson, Chevallier, Cox, David Parkinson, Feroz, Gregory, Hastings, Hobson, Huterer, Jaynes, Jeffreys, Kass, Linder, MacKay, Metropolis, Mukherjee, Mukherjee, Parkinson, Parkinson, Pia Mukherjee, Seo, Skilling, Trotta, Trotta, Trotta   +29 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Goals and Psychological Accounting [PDF]

We model how people formulate and evaluate goals to overcome self-control problems. People often attempt to regulate their behavior by evaluating goal-related outcomes separately (in narrow psychological accounts) rather than jointly (in a broad account).
Koch, Alexander K., Nafziger, Julia
core  

Planetary Science Goals for the Spitzer Warm Era [PDF]

, 2007
The overarching goal of planetary astronomy is to deduce how the present collection of objects found in our Solar System were formed from the original material present in the proto-solar nebula.
B. Bhattacharya, C. M. Lisse, D. Trilling, E. Ryan, H. B. Hammel, J. Emery, J. Stansberry, Lisa J. Storrie-Lombardi, M. V. Sykes, Nancy A. Silbermann, Y. Fernandez   +10 more
core   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Soccer: is scoring goals a predictable Poissonian process? [PDF]

, 2000
The non-scientific event of a soccer match is analysed on a strictly scientific level. The analysis is based on the recently introduced concept of a team fitness (Eur. Phys. J. B 67, 445, 2009) and requires the use of finite-size scaling.
Chamblin, A., Reall, H., Shinkai, H., Shiromizu, T.   +3 more
core   +3 more sources

Estimation of ecosystem service value in Huixian Karst National Wetland Park based on equivalent factor method

International Journal of Digital Earth
Huixian Wetland Park's sustainable development will be aided by an analysis of the park's shifting ecosystem service value trend and an assessment of its ecological sustainable development potential.
Yuxin He, Lanwei Zhu, Liduo Dou, Meiqing Wu, Yifei Guo   +4 more
doaj   +1 more source