Results 41 to 50 of about 724,087 (299)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Animals, 2022 Twenty-four Alpine doelings, initial 25.3 ± 0.55 kg body weight (BW) and 10.4 ± 0.11 mo of age, and 24 Katahdin ewe lambs, 28.3 ± 1.02 kg BW and 9.6 ± 0.04 mo of age, were used to determine effects of dietary inclusion of Sericea lespedeza (Lespedeza ...
Wei Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian +9 more
core +2 more sources
Frontiers in Nutrition, 2020 Human milk contains prebiotic components, such as human milk oligosaccharides (HMOs), which stimulate the growth of specific members of the infant gut microbiota (e.g., Bifidobacteria).
Sophie Gallier +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Journal of Veterinary Diagnostic Investigation, 1995 Cholangiomas (bile duct adenomas) are seen mainly in old dogs and cats. They have also been reported in swine, rats, birds 2,7 and mice. Reports of adenomas of the gall bladder are rare, occurring mainly in cattle. There are individual reports of cholangiomas in a reindeer and a green iguana, as well as several reports in white perch. To our knowledge,
M, Puette, S, Hafner
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
AnimalsThe study was conducted to determine appropriate numbers and times of daily gas measurements to estimate total daily methane (CH4) emission of meat goats using a GreenFeed system (GFS). A replicated 4 (four measurement protocols) × 4 (four periods) Latin
Dereje Tadesse +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source