Results 61 to 70 of about 695,458 (310)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Influence of Sheep Age at First Calving on the Productive Performance of Lambs from Tsigai breed

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to determine the effects of age on reproductive indices and on growth performances, carcass and meat quality of Tsigai lambs coming from young females (8 months age), in order to improve meat quality and meat sensory ...
Elena Ilișiu   +7 more
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Goat situation and research projects in Portugal [PDF]

open access: yes, 2003
Portugal Goat Information In 2000 the goat population of Portugal was 623 000 heads, 162 000 less than in 1997 (785 000 heads) 188 000 less than 1995, confirming a downward trend since 1992 (862 000 heads). The dominant region is the Alentejo (South)
Teixeira, Alfredo
core   +3 more sources

Effects of the concentration and nature of total dissolved solids in drinking water on feed intake, nutrient digestion, energy balance, methane emission, ruminal fermentation, and blood constituents in different breeds of young goats and hair sheep

open access: yesAnimal Nutrition
Understanding how different livestock species and breeds respond to consumption of brackish water could improve usage of this resource. Therefore, Angora, Boer, and Spanish goat doelings and Dorper, Katahdin, and St. Croix ewe lambs (6 animals per animal
Amlan Kumar Patra   +7 more
doaj   +1 more source

The Main Index of Carcasses Conformation at Young Sheep

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Research purpose is to obtain information on the development of carcasses obtained from Tsigai  race and its hybrids  with Suffolk  and German blackface breeds.
Elena Ilișiu   +7 more
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Preliminary investigations indicate that the lack of growth in Indonesian goat consumption is linked to negative perceptions of goat meat [PDF]

open access: yes, 2013
The present paper discusses goat consumption by consumers in Makassar, Indonesia, on the basis of interviews with households from April to May 2009, using a survey that included questions on criteria for purchasing meat, attitudes to goat meat, goat and ...
Natsir, A.   +4 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Changes in goat production systems in Europe and interrelations with the dairy goat industry and european regulations [PDF]

open access: yes, 2006
International audienceAn overlook on the diversity of goat production systems in Europe, shows that they have faced important changes for 30 years: settling, intensification and specialization have been common tendencies.
Le Jaouen, J.C., Dubeuf, Jean-Paul
core   +2 more sources

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