Results 71 to 80 of about 724,087 (299)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

SEGMENTING NICHE GOAT-MEAT MARKETS [PDF]

This research report provides an examination of the ratings of an important sensory attribute of chevon (goat meat) with that of beef and pork. Results from an analysis of variance of comparative ratings of the flavor of chevon and that of beef and pork ...
Whitehead, Jackie, Mobini, Seyedmedhi, Brown, Nathaniel B., Jr., Thomas, Marc, Nelson, Mack C.   +4 more
core  

Goat situation and research projects in Portugal [PDF]

, 2003
Portugal Goat Information In 2000 the goat population of Portugal was 623 000 heads, 162 000 less than in 1997 (785 000 heads) 188 000 less than 1995, confirming a downward trend since 1992 (862 000 heads). The dominant region is the Alentejo (South)
Teixeira, Alfredo
core   +2 more sources

The Goat (vol. 1, no. 3) 1968

, 1968
"The Goat" was an "underground" paper published by a group on the Springfield College campus. This radical newspaper was create by a student group Ad Hoc Committee for Student Self-Determination.
Ad Hoc Committee for Student Self Determination
core   +1 more source

Maternal Tributyrin Supplementation During the Perinatal Period Is Associated with Improved Ewe Milk Quality and Lamb Growth Performance, Immunity, and Antioxidant Status

Veterinary Sciences
This study investigated the effects of tributyrin supplementation on the immune and antioxidant status of lambs born to perinatal Hu ewes with negative energy balance (NEB) at 75%. Twenty healthy Hu ewes (average body weight 45.00 ± 5.00 kg) with similar
Xu-Nan Gao, Xin-Le Zhang, Jian-Xin Zuo, Yuan-Xiao Wang, Pei-Yong Chen, Yan-Li Zhang, Feng Wang, Yi-Xuan Fan   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Genome-wide analysis of DNA Methylation profiles on sheep ovaries associated with prolificacy using whole-genome Bisulfite sequencing

BMC Genomics, 2017
Background Ovulation rate and litter size are important reproductive traits in sheep with high economic value. Recent work has revealed a potential link between DNA methylation and prolificacy.
Yanli Zhang, Fengzhe Li, Xu Feng, Hua Yang, Aoxiang Zhu, Jing Pang, Le Han, Tingting Zhang, Xiaolei Yao, Feng Wang   +9 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Comparative Morphometric Study of Saanen and Indigenous Goats, in Northern Pakistan

Journal of Bioresource Management
Goats play an essential role in sustaining rural communities in Pakistan by providing milk, meat, and income under diverse production systems. This study compared the morphometric features of exotic Saanen goats with local breeds (Beetal, Kaghani, Gaddi,
Nadar Khan, Ihsan uddin, Sohail Khan, Hayat Ullah Khan, Muhammad Suleman   +4 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source