Results 71 to 80 of about 693,575 (310)

Goat System Productions: Advantages and Disadvantages to the Animal, Environment and Farmer [PDF]

, 2017
Goats have always been considered very useful animals. Goats success is related to its excellent adaptability to the difficult mountain conditions, extreme weather and low value feed acceptance, versatile habits and high production considering their size.
Maria João Lima, José Manuel Costa, Lima, M. J. Reis, Costa, José, Monteiro, António, António Monteiro   +5 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Maternal Tributyrin Supplementation During the Perinatal Period Is Associated with Improved Ewe Milk Quality and Lamb Growth Performance, Immunity, and Antioxidant Status

Veterinary Sciences
This study investigated the effects of tributyrin supplementation on the immune and antioxidant status of lambs born to perinatal Hu ewes with negative energy balance (NEB) at 75%. Twenty healthy Hu ewes (average body weight 45.00 ± 5.00 kg) with similar
Xu-Nan Gao, Xin-Le Zhang, Jian-Xin Zuo, Yuan-Xiao Wang, Pei-Yong Chen, Yan-Li Zhang, Feng Wang, Yi-Xuan Fan   +7 more
doaj   +1 more source

Genome-wide analysis of DNA Methylation profiles on sheep ovaries associated with prolificacy using whole-genome Bisulfite sequencing

BMC Genomics, 2017
Background Ovulation rate and litter size are important reproductive traits in sheep with high economic value. Recent work has revealed a potential link between DNA methylation and prolificacy.
Yanli Zhang, Fengzhe Li, Xu Feng, Hua Yang, Aoxiang Zhu, Jing Pang, Le Han, Tingting Zhang, Xiaolei Yao, Feng Wang   +9 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparative Morphometric Study of Saanen and Indigenous Goats, in Northern Pakistan

Journal of Bioresource Management
Goats play an essential role in sustaining rural communities in Pakistan by providing milk, meat, and income under diverse production systems. This study compared the morphometric features of exotic Saanen goats with local breeds (Beetal, Kaghani, Gaddi,
Nadar Khan, Ihsan uddin, Sohail Khan, Hayat Ullah Khan, Muhammad Suleman   +4 more
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

GOAT-like and ghrelin-like immunoreactivity in goldfish intestine detected by immunohistochemistry.

, 2017
Figure shows transversal representative sections of intestine showing GOAT-like (A1 and A2, red) and ghrelin-like (B, green) immunoreactivity, and merged images of GOAT and ghrelin (C, yellow).
Ana Isabel Valenciano (3726982), Miguel Gómez-Boronat (3726979), Ayelén Melisa Blanco (3726970), Suraj Unniappan (235924), Roman Yufa (3726973), María Jesús Delgado (3726976), Ángel Luis Alonso-Gómez (3726985)   +6 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source