Results 151 to 160 of about 2,502,296 (297)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Comparative lipidomic profiling of African trypanosomes reveals metabolic distinctions impacting pan-species drug development. [PDF]

PLoS Negl Trop Dis
Dickie EA, Weidt SK, Haggarty J, Blackburn G, Doherty MK, Ritchie R, Paxton E, Young S, Whitfield PD, Smith TK, Morrison LJ, Barrett MP, Steketee PC.   +12 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Construction and Comparison of Molecular Identification Methods for <i>Mannheimia haemolytica</i>. [PDF]

Microorganisms
Yang Z, Miao Y, Mou H, Zhang S, Yang L, Xu D, Fu L, Shen K, Li Z, Zhao L, Yu Y.   +10 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

An Overview of Respiratory Diseases in Goats

Abstract: Goats and sheep can provide meat, milk, leather, and wool, making them valuable assets for the global livestock business, particularly in Southeast Asia, the Mediterranean region, and African nations. Respiratory diseases are the primary cause of death for these animals, accounting for about half of their deaths.
openaire   +2 more sources

Vector-Borne Hemopathogens in Goats: Molecular Identification and Genetic Diversity in Sulaymaniyah, Iraq. [PDF]

Vet Med Int
Abdullah SH.
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Total protease activity in goat milk

, 2011
Milk protein system exerts a crucial role from the point of view of both milk nutritional quality and technological properties. It is a dynamic system: milk caseins and whey proteins, which are synthesized by the mammary cells, undergo the action of ...
C. Gigliotti, A. Caroli, O. Bulgari, G. Pagnacco   +3 more
core  

Caprine Brucellosis: Seroprevalence, Risk Factors, Public Awareness and Zoonotic Implications in Pastoral and Agro-Pastoral Production Systems of Benatsemay District, Southern Ethiopia. [PDF]

Environ Health Insights
Seyoum W, Daniel T, Kinfe G, Tora E, Abebe H, Worku A, Wodajo W, Gelgelo K.   +7 more
europepmc   +1 more source