Results 131 to 140 of about 353,370 (309)

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Komunikasi Pemasaran CV Laktatridia dalam Memasarkan Susu Kambing (Studi Kasus Komunikasi Pemasaran dalam Mengenalkan dan Meningkatkan Penjualan Susu Kambing di CV Laktatridia Ciwidey, Bandung) [PDF]

, 2011
This research uses case study metode wich would give such as comprehensive description of all marketing communication of the CV Laktatridia, complete with its implementation and problems that they are facing in doing the marketing of the goats milk.The ...
Saidah, I. (Iis)
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Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Sabun Susu Kambing Virgin Coconut Oil Dapat Meningkatkan Kesehatan Kulit melalui PH dan Bakteri Baik (Bakteri Asam Laktat) Serta Meningkatkan Pendapatan Masyarakat [PDF]

, 2012
This research aims to determine the effect of giving the level of VCO (Virgin Coconut Oil) on the manufacture of goat milk soap on the pH value, total and lactat acid bacterial colonies.
Purwati, E. (Endang), Suharto, E. L. (El), Vebriyanti, E. (Ely)   +2 more
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A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Livestock Systems and Their Performance in Poor Endowment Regions of India [PDF]

The study pertaining to the semi-arid tropic region of the country, which has maximum concentration of livestock, has identified livestock systems, investigated their performance, and determined their carrying capacity. Seven major livestock systems have
Chandel, B.S., Malhotra, Ravinder
core   +1 more source

Kualitas Susu Kambing Perah Peranakan Ettawa yang Diberi Suplementasi Protein Terproteksi dalam Wafer Pakan Komplit Berbasis Limbah Agroindustri [PDF]

, 2012
The objectives of this research were to evaluate the effect of protected protein supplementation in complete feed wafer based on agroindustrial by-product on milk quality of Ettawa Crossbreed goat. This research were conducted from January to May 2012 at
Muktiani, A. (Anis), Prasetiyono, B. W. (Bambang), Utari, F. D. (Farida)   +2 more
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PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

α_S1-casein genetic variants in Sarda goat breed [PDF]

, 2003
Sardinia plays an important role in Italian goat breeding; this is due not only to the high extent of its patrimony and production, but also to the fact that the main breed, the Sarda goat, represents an interesting biodiversity source.
Bini, Pier Paolo, Carcangiu, Vincenzo, Chianese, Lina, Ghibellini, Antonella, Mauriello, Rosalba, Vacca, Giuseppe Massimo   +5 more
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