Results 51 to 60 of about 138,929 (305)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom [PDF]
, 2011 The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics
Bossers, A. +33 more
core +1 more source
Indian Journal of Animal Sciences, 2016 Male Barbari kids (56), 7 to 8 months of age and weighing19.2± 2.9 kg were randomly divided into 4 equal groups to assess the effect of source (inorganic or organic) and level of Zn, Cu, Co and Mn on intake and growth performance.
U B CHAUDHARY +5 more
doaj +1 more source
Development of real-time RT-PCR assay for diagnosis of viral enteritis in neonatal goat kids
Indian Journal of Animal Sciences, 2020 Rotavirus gastroenteritis is a worldwide disease affecting primarily infants, young children and young ones of wide variety of mammalian and avian species.
SAPNA PRAJAPATI +5 more
doaj +1 more source
Indian Journal of Animal Sciences, 2022 Biotin supplementation to the sperm cryopreservation medium appears to be beneficial in enhancing the in vitro sperm survival without affecting the fertilizing ability.
Ravi Ranjan +5 more
doaj +1 more source
Journal of Veterinary Diagnostic Investigation, 1995 Cholangiomas (bile duct adenomas) are seen mainly in old dogs and cats. They have also been reported in swine, rats, birds 2,7 and mice. Reports of adenomas of the gall bladder are rare, occurring mainly in cattle. There are individual reports of cholangiomas in a reindeer and a green iguana, as well as several reports in white perch. To our knowledge,
M, Puette, S, Hafner
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Goats show higher behavioural flexibility than sheep in a spatial detour task [PDF]
, 2021 The ability to adapt to changing environments is crucial for survival and has evolved based on socio-ecological factors. Goats and sheep are closely related, with similar social structures, body sizes and domestication levels, but different feeding ...
McElligott, A. +4 more
core +1 more source
Indian Journal of Animal Sciences, 2021 This study was designed to investigate milk and circulating profiles of progesterone (P4) and pregnancy-associated glycoprotein (PAG) during early pregnancy and to determine their associations with the foetal numbers in Jakhrana goats.
N SHARMA, S P SINGH, A BHARADWAJ
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source