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Mucins, Mucus, and Goblet Cells

Chest, 2018
The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and macromolecules. The major macromolecular components of mucus are the mucin glycoproteins, which are critical for local defense of the airway. There are three classes of mucins in the airways: those that are secreted but do not polymerize (MUC7), those that are ...
Jonathan, Ma   +2 more
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Goblet Cells Secretion and Mucogenesis

Annual Review of Physiology, 1990
In the final discussions of the last Ciba Symposium on Mucus and Mucosa (London, 1984), I voiced my impression that, in this gelatinous drama of mucus formation, several scripts were looking for characters, and some characters were looking for roles. Now, four years later, we have been able to locate a few of the missing characters and see them play ...
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Management of goblet cell carcinoid

Journal of Surgical Oncology, 2006
AbstractBackground and ObjectivesGoblet cell carcinoid, a rare tumor of intermediate malignant potential, is known to account for a significant minority of appendiceal neoplasms. Sixteen new cases of gastrointestinal goblet cell carcinoid were reviewed to describe their presentation, treatment, and outcome.MethodsA review of 16 cases from a single ...
John C, Byrn   +4 more
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Goblet cell diversity

Science, 2021
Gut Physiology An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nystrom et al. discovered that goblet cells are not all the same along the length of the gut; rather, they form different functional ...
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Goblet Cells of the Human Conjunctiva

Archives of Ophthalmology, 1981
We correlated histologic findings concerning conjunctival goblet cells with findings concerning the mucous membrane surfaces of the conjunctiva. Ten biopsy specimens were obtained from the upper tarsal conjunctiva and ten from the perilimbal bulbar conjunctiva.
J V, Greiner   +4 more
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Goblet cell fine structure

The Anatomical Record, 1966
AbstractAlthough the role of the goblet cell in mucous secretion has been known since 1837, the actual process by which mucous is formed by the cell still is open to question. There is a known proliferation of the Golgi membranes during the early formation of mucous within peripheral Golgi vacuoles. However, there also is a concomitant proliferation of
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Intestinal goblet cell mucus: Isolation and identification by immuno-fluorescence of a goblet cell glycoprotein

Journal of Cell Science, 1973
ABSTRACTA high-molecular-weight glycoprotein (HMG), representing the majority of the soluble glycoprotein hexosamine and hexose in the intestine, was isolated by Sepharose 4B chromatography from high-speed supernatants of rat small intestinal homogenate.
J, Forstner   +3 more
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Fate of Goblet Cells in Experimental Colitis

Digestive Diseases and Sciences, 2002
We sought to correlate the characteristic changes in goblet cell morphology in the chronically inflamed large intestine of 1L10-/- mice to specific changes in goblet cell gene expression. In healthy as well as IL10-/- mice, marked differences were found among the large intestinal regions in goblet cell morphology and gene expression.
Makkink, MK (Mireille)   +11 more
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Goblet or Signet Ring Cells

Advances in Anatomic Pathology, 2009
Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix. It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma. There has been a general lack of clinicopathologic parameters that can be reliably used to predict the clinical course and patient outcome.
Hanlin L, Wang, Deepti, Dhall
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Immune Regulation of Goblet Cell Development

International Archives of Allergy and Immunology, 1987
In rats, goblet cells were found in the bronchiole epithelium surrounding enlarged lymphoid noduli. The goblet cell number increased with age. Old rats had goblet cells in the columnar epithelium. Immunization with aerosolized antigen increased goblet cell hyperplasia in bronchioli with a luminal diameter of 0.5–1.0 mm.
S, Ahlstedt, I, Enander
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