Results 41 to 50 of about 5,005,509 (181)

Mutational landscape of goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix is distinct from typical carcinoids and colorectal adenocarcinomas [PDF]

Modern Pathology, 2018
There is limited data on the spectrum of molecular alterations in goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix. We used next generation sequencing to determine mutations of potential pathogenetic and therapeutic significance in this rare group of tumors.
Melanie, Johncilla, Matthew, Stachler, Joseph, Misdraji, Mikhail, Lisovsky, Masato, Yozu, Neal, Lindeman, Gregory Y, Lauwers, Robert D, Odze, Amitabh, Srivastava   +8 more
openaire   +2 more sources

Appendiceal Goblet Cell Adenocarcinoma: A Historically Informed Reading of 6 Cases [PDF]

Archives of Pathology & Laboratory Medicine, 2022
Context.— Appendiceal goblet cell adenocarcinoma is an uncommon appendiceal neoplasm that is typically diagnosed incidentally to a presentation of acute appendicitis. Over the years, there have been many changes to the histologic evaluation and classification of this neoplasm, culminating in the most recent ...
Yan, Wang, Ali, Shahabi, Agnes, Loeffler
openaire   +2 more sources

Goblet cell carcinoid of the rectum: a case report

Surgical Case Reports, 2020
Background Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin.
Yoshiyuki Inoue, Hisanaga Horie, Yuko Homma, Ai Sadatomo, Makiko Tahara, Koji Koinuma, Hironori Yamaguchi, Toshiki Mimura, Atsushi Kihara, Alan Kawarai Lefor, Naohiro Sata   +10 more
doaj   +1 more source

Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape

Frontiers in Oncology, 2021
Goblet cell adenocarcinoma (GCA) is a rare amphicrine tumor and difficult to diagnose. GCA is traditionally found in the appendix, but extra-appendiceal GCA may be underestimated.
Dong-Liang Lin, Li-Li Wang, Peng Zhao, Wen-Wen Ran, Wei Wang, Long-Xiao Zhang, Ming Han, Hua Bao, Kaihua Liu, Xue Wu, Yang Shao, Yang Shao, Xiao-Ming Xing   +12 more
doaj   +1 more source

Amphicrine Carcinoma of the Duodenum: A Rare Entity [PDF]

Journal of Clinical and Diagnostic Research
Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. It is different from adenocarcinoma and Mixed Neuroendocrine-Non neuroendocrine neoplasms (MiNEN).
Supriya Prasad, Renu Sukumaran, Arun Sankar, Madhu Muralee, Priya Appanraj   +4 more
doaj   +1 more source

Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients ...
In Ho Choi, Dong Won Kim, Sang Yun Ha, Yoon-La Choi, Hee Jeong Lee, Joungho Han   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism [PDF]

, 2010
Goblet cells are key contributors to intestinal mucosal barrier function through their role in production of mucins and other important secretory products, which include trefoil factor 3 (TFF3) and resistin like molecule β (RETNLB).
Croix, Jennifer A.
core  

Mixed Goblet Cell Carcinoid-Adenocarcinoma: A Case Series [PDF]

, 2017
INTRODUCTION: Mixed goblet cell carcinoid-adenocarcinoma (GCC) tumors are a group of rare heterogenous neoplasms of the appendix accounting for \u3c 5% of all primary appendiceal tumors. They are characterized as an intermediate between classic carcinoid
Espinosa, Jairo, M.D., Shebrain, Saad, M.D., Miladore, Julia, M.D., Truong, Timothy, Collins, John T., Munene, Gitonga, M.D.   +5 more
core   +1 more source