Results 61 to 70 of about 5,005,509 (181)

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Incidental Finding of Goblet Cell Adenocarcinoma Post Appendectomy: A Rare Case Report

Dubai Medical Journal
Introduction: One of the most frequent etiologies of an acute abdomen is appendicitis, which ranks as one of the primary reasons for surgical emergencies globally.
Fathima Hana Mohamed Naushad, Shameema Alam, Aliya Ishaq   +2 more
doaj   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

A unique case of pulmonary minimally invasive mucinous adenocarcinoma arising from atypical goblet cell hyperplasia in the bronchial epithelium of a 9-year-old girl

BMC Pediatrics
Background Pulmonary mucinous adenocarcinoma without congenital pulmonary airway malformation (CPAM) is extremely rare in pediatric patients. Here, we report a unique case of minimally invasive mucinous adenocarcinoma without CPAM in a child and provide ...
Ping Zhou, Cuomu Zhaxi, Lili Jiang
doaj   +1 more source

Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report

World Journal of Surgical Oncology, 2010
Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum. A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen. Exploratory laparotomy revealed perforation with a diameter
Karakaş Barış R, Erkasap Serdar, Paşaoğlu Özgül, İhtiyar Enver, Yaşar Fatih N   +4 more
doaj   +1 more source

High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus. [PDF]

PLoS ONE, 2015
Goblet cells may represent a potentially successful adaptive response to acid and bile by producing a thick mucous barrier that protects against cancer development in Barrett's esophagus (BE).
Amitabh Srivastava, Kevin L Golden, Carissa A Sanchez, Karen Liu, Pui Yee Fong, Xiaohong Li, David S Cowan, Peter S Rabinovitch, Brian J Reid, Patricia L Blount, Robert D Odze   +10 more
doaj   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

The primary goblet cell adenocarcinoma of the rectum: A Case Report

, 2022
Abstract Goblet cell adenocarcinoma (GCA) is a rare tumor, and it is characterized by its unique combination of neuroendocrine and adenocarcinoma. GCA occurs mainly in the appendix. Currently, there is no primary GCA of the rectum in the 2019 World Health Organization classification of colorectal tumors.
Ruirui Fan, Jie Gao, Dehua Zeng, Xiaoyu Fu, Mingzhi Lu   +4 more
openaire   +1 more source

Comprehensive and reproducible grading of the Updated Sydney System in gastric biopsies using artificial intelligence: multi‐pathologist validation and a reader study

Histopathology, EarlyView.
SydneyMTL is an interpretable multi‐task model providing four‐level grading for the five Sydney System attributes. By significantly improving diagnostic concordance and reducing reading time, it offers a robust clinical tool to alleviate pathologist workloads and standardize routine gastric biopsy screening.
Ho Heon Kim, Won Chan Jeong, Yuri Hwang, Gisu Hwang, Kyungeun Kim, Young Sin Ko   +5 more
wiley   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source