Results 201 to 210 of about 4,075,359 (296)

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease. [PDF]

Nat Commun
Lin Q, Zhang S, Zhang J, Jin Y, Chen T, Lin R, Lv J, Xu W, Wu T, Tian S, Ying L, Li X, Huang Z, Niu J.   +13 more
europepmc   +1 more source

Endocervical gastric‐type AIS: a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Histopathology, EarlyView.
Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice, Veronica Parrella, Giulia Scaglione   +2 more
wiley   +1 more source

Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine. [PDF]

Mol Psychiatry
Tanabe M, Kunisawa K, Saito I, Kosuge A, Tezuka H, Kawai T, Kon Y, Yoshidomi K, Kagami A, Hasegawa M, Kubota H, Ojika H, Fujii T, Tochio T, Hirooka Y, Saito K, Nabeshima T, Mouri A.   +17 more
europepmc   +1 more source

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress.

Cell Host Microbe, 2023
Naama M, Telpaz S, Awad A, Ben-Simon S, Harshuk-Shabso S, Modilevsky S, Rubin E, Sawaed J, Zelik L, Zigdon M, Asulin N, Turjeman S, Werbner M, Wongkuna S, Feeney R, Schroeder BO, Nyska A, Nuriel-Ohayon M, Bel S.   +18 more
europepmc   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

Expression Levels of MUC5AC and MUC5B in Airway Goblet Cells Are Associated with Traits of COPD and Progression of Chronic Airflow Limitation. [PDF]

Int J Mol Sci
Pincikova T, Merikallio H, Kotortsi I, Karimi R, Li CX, Lappi-Blanco E, Lindén SK, Padra M, Wheelock ÅM, Nyrén S, Sköld CM, Kaarteenaho RL.   +11 more
europepmc   +1 more source

Comprehensive and reproducible grading of the Updated Sydney System in gastric biopsies using artificial intelligence: multi‐pathologist validation and a reader study

Histopathology, EarlyView.
SydneyMTL is an interpretable multi‐task model providing four‐level grading for the five Sydney System attributes. By significantly improving diagnostic concordance and reducing reading time, it offers a robust clinical tool to alleviate pathologist workloads and standardize routine gastric biopsy screening.
Ho Heon Kim, Won Chan Jeong, Yuri Hwang, Gisu Hwang, Kyungeun Kim, Young Sin Ko   +5 more
wiley   +1 more source

Local Delivery of a Bio‐Engineered IL‐37 Fc‐Fusion Ameliorates Experimental Allergic Asthma in Mice

Allergy, EarlyView.
Lars P. Lunding, Marcel F. Nold, Claudia A. Nold‐Petry, Michael Wegmann   +3 more
wiley   +1 more source

Carbocisteine Reduces Airway Mucus Obstruction and Alters Inflammatory Cell Populations in a Model of Muco‐Obstructive Lung Disease

Immunology &Cell Biology, Volume 104, Issue 8, Page 833-844, September 2026.
Mice with a muco‐obstructive lung disease phenotype were treated with the mucoactive drug, carbocisteine, which resulted in reduced airway mucus and an alteration in the lung mononuclear cell population which was either as a direct effect of, or secondary to, improved mucus clearance.
Peter Ferris, Ryan Brown, Michael McKelvey, Daniel F. McAuley, Marcus A. Mall, Bronwen Connolly, Clifford C. Taggart   +6 more
wiley   +1 more source