Goblet cells need some stress [PDF]
The Journal of Clinical Investigation, 2022 The intestinal tract is protected by epithelium-covering mucus, which is constantly renewed by goblet cells, a specialized type of epithelial cell. Mucus is largely composed of MUC2 mucin, an enormous molecule that poses a high demand on the endoplasmic ...
Malin E.V. Johansson, Gunnar C. Hansson
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Goblet cells mechanically breach the epithelial barrier in gut homeostasis [PDF]
Nature CommunicationsThe intestinal epithelium forms a tight barrier against the harsh luminal environment. Absorptive enterocytes have a polygonal, columnar morphology, while mucus-producing goblet cells exhibit a rounded apical shape and a voluminous cell body, raising the
Justine Creff +10 more
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Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells. [PDF]
PLoS ONE, 2015 Goblet cells are secretory epithelial cells of mucosal tissues that confer protection from environmental agents or pathogens via expression and secretion of soluble mucins.
Laura Contreras-Ruiz, Sharmila Masli
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The role of goblet cells in Crohn’ s disease [PDF]
Cell & BioscienceThe prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, and bacterial factors.
Zichen Wang, Jun Shen
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Inhibition of microRNA-328 Increases Ocular Mucin Expression and Conjunctival Goblet Cells [PDF]
Biomedicines, 2023 We previously reported anti-miR-328 therapy for dry eye disease (DED). Since decreased mucin secretion is a risk factor for DED, we aimed to explore whether anti-miR-328 affects mucin expression and goblet cells.
Jackson Choo +6 more
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DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation [PDF]
Advanced ScienceThe colonic mucus barrier, dependent on goblet cell‐secreted mucin2 (Muc2), prevents microbial invasion. Compound exocytosis enables the rapid, high‐volume release of mucus from goblet cells; its underlying mechanisms, however, remain unclear.
Ying Wang +9 more
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The role of goblet cells in viral pathogenesis [PDF]
The FEBS Journal, 2021 Goblet cells are specialized epithelial cells that are essential to the formation of the mucus barriers in the airways and intestines. Armed with an arsenal of defenses, goblet cells can rapidly respond to infection but must balance this response with maintaining homeostasis.
Valerie Cortez, Stacey Schultz‐Cherry
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Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Journal of Inflammation Research, 2021 Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery ...
Yang S, Yu M
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Goblet of fire: how Chlamydia ignites region-specific colitis by hijacking goblet cells [PDF]
The Journal of Clinical InvestigationCrohn’s disease can occur anywhere along the small and/or large intestines, but most commonly occurs in the terminal ileum or ascending colon. Factors governing this region-specific inflammation are poorly understood. In this issue of the JCI, Spencer et
Declan F. McCole
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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
Life Science Alliance, 2022 The histone methyltransferase Mll1 controls intestinal secretory cell fate by promoting Wnt-driven Paneth and restricting Mapk-dependent goblet cell differentiation through regulation of Gata4/6 transcription factors Differentiation and lineage ...
Johanna Grinat +8 more
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