Results 61 to 70 of about 4,473,643 (292)

Peningkatan Jumlah Sel Goblet Aktif pada Duodenum Broiler yang Dipapar Heat Stress

, 2011
The purpose of this study was to know the intestinal barrier response by observing number ofactivated goblet cells as mucin producer in the duodenum of broiler exposed by heat stress.
Yunus, Muchammad, Yuliati, M.G.A, Annisa, Mutiara, Arimbi   +3 more
core   +1 more source

Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis

Gut Microbes
Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare, Graham A. D. Blyth, Rita Hannawayya, Karina M. Cirone, Geeta Kilari, Priyoshi Lahiri, Yi Lin Tan, Aydin Ivan Herik, Yongpeng Fu, Hayley Gorman, Björn Petri, Kris Chadee, Eduardo R. Cobo   +12 more
doaj   +1 more source

Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants.

PLoS ONE, 2019
To use human limbal explants as an alternative source for generating conjunctival epithelium and to determine the effect of interleukin-13 (IL-13) on goblet cell number, mucin expression, and stemness. Human limbal explants prepared from 17 corneoscleral
Andrea Stadnikova, Peter Trosan, Pavlina Skalicka, Tor Paaske Utheim, Katerina Jirsova   +4 more
doaj   +1 more source

Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.

PLoS ONE, 2013
The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can ...
Victoria E McGilligan, Meredith S Gregory-Ksander, Dayu Li, Jonathan E Moore, Robin R Hodges, Michael S Gilmore, Tara C B Moore, Darlene A Dartt   +7 more
doaj   +1 more source

Keeping goblet cells unstressed: new insights into a general principle. [PDF]

EMBO J
The regulation of unfolded protein response (UPR) sensors has been studied for over 20 years, but IRE1β has remained a mystery. IRE1β is highly expressed in goblet cells: specialized epithelial cells that secrete mucus.
Bertolotti A.
europepmc   +4 more sources

Is the Intestinal Goblet Cell a Major Immune Cell? [PDF]

Cell Host & Microbe, 2014
Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis.
Johansson, Malin E.V., Hansson, Gunnar C.   +1 more
openaire   +2 more sources

Absence of gut microbiota impairs depletion of Paneth cells but not goblet cells in germ-free Atoh1lox/lox VilCreERT2 mice. [PDF]

, 2023
Mouse atonal homolog 1 (Math1/Atoh1) is a basic helix-loop-helix transcription factor important for the differentiation of secretory cells within the intestinal epithelium.
Kellmann, Philipp, Gomez de Agüero, Mercedes, Stephanie C. Ganal-Vonarburg, Mercedes Gomez de Agüero, Jakob Zimmermann, Mohsin Hassan, Philipp Kellmann, Stefania Huber, Edoardo Lazzarini, Huber, Stefania, Lazzarini, Edoardo, Hassan, Mohsin, Juanola, Oriol, Moghadamrad, Sheida, Zimmermann, Jakob, Oriol Juanola, Ganal-Vonarburg, Stephanie C, Sheida Moghadamrad   +17 more
core   +2 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Secretagogue Response of Goblet Cells and Columnar Cells in Human Colonic Crypts

, 1999
Crypts of Lieberkühn were isolated from human colon, and differential interference contrast microscopy distinguished goblet and columnar cells.
Halm, Dan R., Halm, Susan T.
core   +3 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source