Results 141 to 150 of about 2,695 (215)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

Endocervical gastric‐type AIS: a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Histopathology, EarlyView.
Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice, Veronica Parrella, Giulia Scaglione   +2 more
wiley   +1 more source

Protein Corona‐Coated Crystal Silica From Sandstorms Amplifies Allergic Rhinitis by Regulating Epithelial Integrity in Mice and Human Nasal Epithelia

Allergy, EarlyView.
Cuishuang Dong, Xu Zhang, Haoyue Wang, Jiajing Cui, Shuai Han, Yibo Wang, Huanying Zhao, Yang Song, Yuan Zhang, Xiaobo Li   +9 more
wiley   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

Comprehensive and reproducible grading of the Updated Sydney System in gastric biopsies using artificial intelligence: multi‐pathologist validation and a reader study

Histopathology, EarlyView.
SydneyMTL is an interpretable multi‐task model providing four‐level grading for the five Sydney System attributes. By significantly improving diagnostic concordance and reducing reading time, it offers a robust clinical tool to alleviate pathologist workloads and standardize routine gastric biopsy screening.
Ho Heon Kim, Won Chan Jeong, Yuri Hwang, Gisu Hwang, Kyungeun Kim, Young Sin Ko   +5 more
wiley   +1 more source

Carbocisteine Reduces Airway Mucus Obstruction and Alters Inflammatory Cell Populations in a Model of Muco‐Obstructive Lung Disease

Immunology &Cell Biology, EarlyView.
Mice with a muco‐obstructive lung disease phenotype were treated with the mucoactive drug, carbocisteine, which resulted in reduced airway mucus and an alteration in the lung mononuclear cell population which was either as a direct effect of, or secondary to, improved mucus clearance.
Peter Ferris, Ryan Brown, Michael McKelvey, Daniel F. McAuley, Marcus A. Mall, Bronwen Connolly, Clifford C. Taggart   +6 more
wiley   +1 more source

Haematological and histopathological monitoring of monosodium glutamate–supplemented feeding in rainbow trout (Oncorhynchus mykiss): A possible modelling for a single health approach

Journal of Fish Biology, EarlyView.
Abstract The aim of this study was to investigate the potential effects of monosodium glutamate (MSG), a known flavour enhancer added to many ready‐to‐eat foods, as a feed additive in rainbow trout (Oncorhynchus mykiss). Evaluating the effects of MSG on aquatic organisms will fill the knowledge gap in this field by monitoring the haematological indices
Gonca Alak, Furkan Bedir, Aslı Çilingir Yeltekin, Serkan Yıldırım, Eylül Ecrin Ekiz, Nisa Gül Yiğit, Esat Mahmut Kocaman, Metin Kiliçlioğlu, Tuba Akbey, Elif Zeynep Özçelik, Koray Koşar, Muhammet Alaeddin Ekiz, Arzu Ucar, Ahmet Atmaca, Melihat Pilgi, Veysel Parlak, Muhammed Atamanalp   +16 more
wiley   +1 more source

Paracamallanus cyathopharynx (Baylis, 1923) Infection in Clarias gariepinus (Burchell, 1822): Linking the Morphology of Wound‐Inflicting Structures to Histopathology

Journal of Fish Diseases, EarlyView.
ABSTRACT Paracamallanus cyathopharynx (Baylis, 1923) specimens were collected from the rectum of the African sharptooth catfish, Clarias gariepinus in Lake Heritage, Crocodile River in the Limpopo River system and in the Vaal River below the Vaal Dam. Attached and unattached parasites were studied with light and scanning electron microscopy along with ...
Thabo Kenneth Matea, Annemariè Avenant‐Oldewage   +1 more
wiley   +1 more source