Toll-like receptor 4 damages the intestinal epithelial cells by activating endoplasmic reticulum stress in septic rats [PDF]
PeerJBackground The severity of acute gastrointestinal injury (AGI) is a critical determinant of survival in sepsis. However, there is no specifically interventional management for gastrointestinal dysfunction.
Xue Wu, Jilin Yang, Xin Bao, Yijie Wang
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Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
The EMBO Journal, 2023 Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots +9 more
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Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. [PDF]
PLoS ONE, 2013 Intestinal epithelial cells (IECs) regulate the absorption and secretion of anions, such as HCO3(-) or Cl(-). Bestrophin genes represent a newly identified group of calcium-activated Cl(-) channels (CaCCs).
Go Ito +15 more
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The infection of chicken tracheal epithelial cells with a H6N1 avian influenza virus. [PDF]
PLoS ONE, 2011 Sialic acids (SAs) linked to galactose (Gal) in α2,3- and α2,6-configurations are the receptors for avian and human influenza viruses, respectively. We demonstrate that chicken tracheal ciliated cells express α2,3-linked SA, while goblet cells mainly ...
Ching-I Shen +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC).
Annika Sünderhauf +16 more
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Aldose reductase inhibition prevents metaplasia of airway epithelial cells. [PDF]
PLoS ONE, 2010 Goblet cell metaplasia that causes mucus hypersecretion and obstruction in the airway lumen could be life threatening in asthma and chronic obstructive pulmonary disease patients.
Umesh C S Yadav +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Disease-specific transcriptional programs govern airway goblet cell metaplasia
HeliyonHypersecretion of airway mucus caused by goblet cell metaplasia is a characteristic of chronic pulmonary inflammatory diseases including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD).
Kuan Li +6 more
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ISOLATION OF STEM CELLS FROM THE MID GUT EPITHELIUM OF CULEX PIPIENS MOSQUITOES (DIPTERA: CULICIDAE) [PDF]
Journal of the Egyptian Society of Parasitology, 2014 Stem cells are undifferentiated cells that remarkable ability to self-renew and produce differentiated cells that support normal development and tissue homeostasis.
H. METWALY +3 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source