Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
The EMBO Journal, 2023 Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots +9 more
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Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. [PDF]
PLoS ONE, 2013 Intestinal epithelial cells (IECs) regulate the absorption and secretion of anions, such as HCO3(-) or Cl(-). Bestrophin genes represent a newly identified group of calcium-activated Cl(-) channels (CaCCs).
Go Ito +15 more
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The infection of chicken tracheal epithelial cells with a H6N1 avian influenza virus. [PDF]
PLoS ONE, 2011 Sialic acids (SAs) linked to galactose (Gal) in α2,3- and α2,6-configurations are the receptors for avian and human influenza viruses, respectively. We demonstrate that chicken tracheal ciliated cells express α2,3-linked SA, while goblet cells mainly ...
Ching-I Shen +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC).
Annika Sünderhauf +16 more
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Goblet cell carcinoid of the appendix
The American Journal of Surgery, 1994 Over the past 15 years, a variant of appendiceal carcinoid has been recognized which is not widely known to the general surgeon. This tumor, variously labeled adenocarcinoid or goblet cell carcinoid, has a more aggressive natural history than classic appendiceal carcinoids and requires a different surgical approach.A survey of the tumor registries of ...
J A, Butler +3 more
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Aldose reductase inhibition prevents metaplasia of airway epithelial cells. [PDF]
PLoS ONE, 2010 Goblet cell metaplasia that causes mucus hypersecretion and obstruction in the airway lumen could be life threatening in asthma and chronic obstructive pulmonary disease patients.
Umesh C S Yadav +4 more
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Disease-specific transcriptional programs govern airway goblet cell metaplasia
HeliyonHypersecretion of airway mucus caused by goblet cell metaplasia is a characteristic of chronic pulmonary inflammatory diseases including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD).
Kuan Li +6 more
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ISOLATION OF STEM CELLS FROM THE MID GUT EPITHELIUM OF CULEX PIPIENS MOSQUITOES (DIPTERA: CULICIDAE) [PDF]
Journal of the Egyptian Society of Parasitology, 2014 Stem cells are undifferentiated cells that remarkable ability to self-renew and produce differentiated cells that support normal development and tissue homeostasis.
H. METWALY +3 more
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Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. [PDF]
PLoS ONE, 2015 Epithelial remodelling in asthma is characterised by goblet cell hyperplasia and mucus hypersecretion for which no therapies exist. Differentiated bronchial air-liquid interface cultures from asthmatic children display high goblet cell numbers. Epidermal
Jeremy C Parker +7 more
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Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.
PLoS ONE, 2013 The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can ...
Victoria E McGilligan +7 more
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