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The airway goblet cell

The International Journal of Biochemistry & Cell Biology, 2003
The two principal features of airway goblet cells are rapid secretion of mucin onto the airway surface and increase in number (hyperplasia) with chronic inhaled 'insult'. The first is associated with homeostasis, the latter with pathophysiology. Myristoylated alanine-rich C kinase (MARCKS) is a key molecule regulating mucin exocytosis, a process also ...
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Goblet or Signet Ring Cells

Advances in Anatomic Pathology, 2009
Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix. It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma. There has been a general lack of clinicopathologic parameters that can be reliably used to predict the clinical course and patient outcome.
Hanlin L, Wang, Deepti, Dhall
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Fate of Goblet Cells in Experimental Colitis

Digestive Diseases and Sciences, 2002
We sought to correlate the characteristic changes in goblet cell morphology in the chronically inflamed large intestine of 1L10-/- mice to specific changes in goblet cell gene expression. In healthy as well as IL10-/- mice, marked differences were found among the large intestinal regions in goblet cell morphology and gene expression.
Makkink, MK (Mireille)   +11 more
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Goblet cell diversity

Science, 2021
Gut Physiology An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nystrom et al. discovered that goblet cells are not all the same along the length of the gut; rather, they form different functional ...
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Immune Regulation of Goblet Cell Development

International Archives of Allergy and Applied Immunology, 2009
In rats, goblet cells were found in the bronchiole epithelium surrounding enlarged lymphoid noduli. The goblet cell number increased with age. Old rats had goblet cells in the columnar epithelium. Immunization with aerosolized antigen increased goblet cell hyperplasia in bronchioli with a luminal diameter of 0.5–1.0 mm.
S, Ahlstedt, I, Enander
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Human intestinal goblet cell mucin

Canadian Journal of Biochemistry, 1976
Goblet cell mucin (GCM) has been purified for the first time from mucosal scrapings of human small intestine. Proteolytic enzymes and organic solvents were avoided during the isolation procedure. The mucin was purified by Sepharose 4B and 2B column chromatography of high-speed supernatant fractions.
I, Jabbal   +3 more
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THE CONJUNCTIVAL GOBLET CELL IN PTERYGIUM FORMATION.

Australian and New Zealand Journal of Ophthalmology, 1980
Histological studies of pterygium pathology, reveals the presence of goblet cells liberally distributed throughout the epithelial surface. This feature poses medical and surgical implications which are discussed.
Frank P. English   +4 more
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Goblet Cell Carcinoid/Carcinoma: An Update

Advances in Anatomic Pathology, 2019
Goblet cell carcinoid (GCC) or goblet cell carcinoma is a unique mixed endocrine-exocrine neoplasm that is almost exclusively seen in the appendix. The hallmark of GCC is the concentric infiltration of the appendiceal wall by small tight clusters, nests or cords of tumor cells that exhibit a goblet cell morphology with a small compressed nucleus and ...
Kuixing, Zhang   +5 more
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The Incidental Goblet Cell Adenocarcinoma

Diseases of the Colon & Rectum, 2022
Tim S, Nugent, Michael E, Kelly
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