Results 71 to 80 of about 2,695 (215)

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Light microscopic study on the absorptive cells and goblet cells in the intestine of adult common carp Cyprinus carpio

The Iraqi Journal of Veterinary Medicine, 2019
The purpose of this study was to describe of some histological structures and histochemical features of the absorptive cells and goblet cells in intestine of common carp. In this study, Fifteen adult male common carp were catching alive from the AL-Forat
Khalid Hadi Kadhim
doaj   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells.

PLoS ONE, 2012
BackgroundMammalian Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that is required for the production of intestinal mucus and Paneth and goblet cell homeostasis. However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-
Yi-Chung Chen, Yu-Fen Lu, I-Chen Li, Sheng-Ping L Hwang   +3 more
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Ultrastructural and histological study of intestine of adult Nile Tilapia (Oreochromis Niloticus) [PDF]

Benha Veterinary Medical Journal
The tilapia intestine is essential for both digestion and nutrient absorption, making its structural analysis crucial for understanding its functional adaptations. This study sought to examine the histological, ultrastructural, and histochemical features
Yasmeen Ali, Aya Tantawy, Eman Khalil
doaj   +1 more source

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

Cell Reports, 2015
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus.
Henry Danahay, Angelica D. Pessotti, Julie Coote, Brooke E. Montgomery, Donghui Xia, Aaron Wilson, Haidi Yang, Zhao Wang, Luke Bevan, Chris Thomas, Stephanie Petit, Anne London, Peter LeMotte, Arno Doelemeyer, Germán L. Vélez-Reyes, Paula Bernasconi, Christy J. Fryer, Matt Edwards, Paola Capodieci, Amy Chen, Marc Hild, Aron B. Jaffe   +21 more
doaj   +1 more source

The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut–kidney axis

Animal Models and Experimental Medicine, EarlyView.
Native postbiotics and paraprobiotics derived from Lactobacillus and Bifidobacterium strains were administered to dextran sulfate sodium–treated C57BL/6 mice to evaluate their impact on kidney inflammation via the gut–kidney axis. Histological analysis and quantitative polymerase chain reaction of autophagy‐related genes (atg5, atg7, atg12, atg13 ...
Fatemeh Haririzadeh Jouriani, Mahnaz Torfeh, Fatemeh Ashrafian, Niloofar Rezaie, Mohsen Mohammadi, Shadi Aghamohammad, Mahdi Rohani   +6 more
wiley   +1 more source

Role of epidermal growth factor receptor activation in regulating mucin synthesis

Respiratory Research, 2001
Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death.
Nadel Jay A
doaj   +1 more source

Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix

World Journal of Surgical Oncology, 2008
Background Goblet cell carcinoids appear less frequently in the appendix than do other carcinoids. In the presented work a case with a goblet cell carcinoid of the appendix is described.
Prangova Diana K, Hadjipetkov Philip, Vlaykova Tatyana, Yovchev Yovcho, Gulubova Maya V, Popharitov Angel   +5 more
doaj   +1 more source