Results 161 to 170 of about 2,213,532 (306)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Patient, community, and clinician beliefs about multi-cancer detection tests: implications for the evidence needed to recommend routine use. [PDF]

J Public Health (Oxf)
Brooks EM, Villalobos G, Miller CA, Alemu R, Bassig BA, Rowe K, May JF, Kaltman R, Nana-Sinkam P, Sayles J, Strayer SM, Fuemmeler BF, Allen C, Krist AH.   +13 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Understanding biosafety practitioner perspectives. [PDF]

Politics Life Sci
Gillum DR, Knight C, Vogel KM.
europepmc   +1 more source

ISA 570 going concern

Die Implementierung und Anwendung des ISA 570, der sich mit der Beurteilung der Un-ternehmensfortführung eines Unternehmens befasst, stellt für viele Unternehmen und Wirtschaftsprüfer eine komplexe Herausforderung dar (Hebenstreit et al., 2013). Ein zentrales Problem stellt das weit verbreitete Missverständnis der Inhalte und Zusammen-hänge des ...
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Experiences of Patients, Family Members and Nurses in Outpatient Cancer Care: A Multi-Method Qualitative Study. [PDF]

Scand J Caring Sci
Azcárate-Cenoz N, Alfaro-Díaz C, Ojer Perea A, Soteras Ramírez MÁ, Arellano Gil C, Beorlegui Murillo P, Esandi N.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Oropouche Virus Infection: A Growing Global Public Health Concern. [PDF]

Indian J Community Med
Sinha R, Kumar D.
europepmc   +1 more source