Results 171 to 180 of about 195,342 (266)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Attention and Suggestions on the Study of Symptom Clusters in ICI Treatment. [PDF]

Health Sci Rep
Qingfei K, Wen X.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Is Knee Osteoarthritis an Inevitable Consequence for Athletes after Anterior Cruciate Ligament Injury? [PDF]

Int J Sports Phys Ther
Rambaud A, Morel G, Prill R, van Melick N, Forelli F.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Abortion Bans and Pregnancy-Related Care Across Physician Specialties: A Qualitative Study.

JAMA Netw Open
Landay S, Newton-Hoe E, Narasimhan S, Beasley A, Adkins J, Neill S.   +5 more
europepmc   +1 more source

'Communication Is Crucial': A Qualitative Study of Patient Expectations of Diagnostic Tests in Emergency Medicine Practice. [PDF]

Health Expect
Gangathimmaiah V, Evans R, Gupta TS, Cupitt K, Oakley S, Carlisle K.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

"Probably a Little Bit of a Hill to Climb": A qualitative study of emergency department providers' perceptions of nonpharmacological pain treatment. [PDF]

PLoS One
Coronado RA, Schlundt DG, Archer KR, Bonnet KR, Brintz CE, Toledo T, Joseph VP, Wolever RQ, Hobbs CS, Patel MP, Collins SP, Storrow AB.   +11 more
europepmc   +1 more source

ISA 570 going concern

Die Implementierung und Anwendung des ISA 570, der sich mit der Beurteilung der Un-ternehmensfortführung eines Unternehmens befasst, stellt für viele Unternehmen und Wirtschaftsprüfer eine komplexe Herausforderung dar (Hebenstreit et al., 2013). Ein zentrales Problem stellt das weit verbreitete Missverständnis der Inhalte und Zusammen-hänge des ...
openaire   +1 more source