Results 191 to 200 of about 2,014,943 (251)

Management turnaround initiatives and auditors' going-concern judgment: Memory for audit evidence. [PDF]

Willekens, Marleen, Bruynseels, Liesbeth, Warlop, Luk, Knechel, W. Robert   +3 more
core  

Living through disclosure: a descriptive phenomenological exploration of adult survivors' experiences of disclosing sexual assault to nurses. [PDF]

J Res Nurs
Dosdale C, Bevan M, Skarparis K.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

"Will it be enough to be respected?": understanding personal, institutional, and societal harms and benefits of genomics research. [PDF]

J Community Genet
Dusic E, Madden D, Rios IE, Restar A, Milan T, Patterson J, Pletta DR, Rabinowitz S, Ramos MA, A Aguayo-Romero R, Baker K, Horowitz CR, Reisner SL.   +12 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Going Concern Opinion, Managementkompetenz und Insolvenzwahrscheinlichkeit eine empirische Analyse

, 2019
Springer Fachmedien Wiesbaden, Heinrichs, Matthias   +1 more
core  

Sources of distrust in precision medicine research: Findings from a focus group study with adults with disabilities. [PDF]

HGG Adv
Peglow K, Aguirre AN, Eitenberger M, Soo-Jin Lee S, Callier S, Spicer P, Rosenblum HA, Sabatello M.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Dementia Caregivers' Preferences for Involvement in Delirium Care During Hospitalization. [PDF]

J Am Geriatr Soc
Golden BP, Johnson B, Block L, Benson C, Merss K, Hansmann KJ, Green-Harris G, Inouye SK, Gilmore-Bykovskyi A.   +8 more
europepmc   +1 more source