Results 191 to 200 of about 195,342 (266)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Understanding Public Perspectives on Direct to Consumer Pharmacogenomic Testing in the UK: A Qualitative Study

Mathieson A, Brunton L, Gillibrand S, Moldovan R, McDermott J.   +4 more
europepmc   +1 more source

Elucidating the phase 1 trial experience among study participants following completion of the INTERCEPT-AD study of sabirnetug (ACU193) for early Alzheimer's disease: a qualitative interview study. [PDF]

Trials
Merikle E, Presnall C, Feaster T, Moxon R, Siemers E, Kerwin D, Cline S.   +6 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Insights From Black Living Kidney Donors: An Interview Study on APOL1 Genetic Testing Experiences. [PDF]

Clin Transplant
Iltis AS, Walsh HA, Baldwin K, McIntosh T, Mohan S, Sawinski D, Goodman MS, DuBois JM.   +7 more
europepmc   +1 more source

Patients' Concerns for Hormone-Replacement Therapy for Menopause. [PDF]

Cureus
Distler KR, Kappers D, Hollingsworth JC.
europepmc   +1 more source

Intensive longitudinal follow-up of cisgender and transgender women engaged in sex work during the three months following initiation of daily oral PrEP: A series of case-studies with mixed-method assessments. [PDF]

PLOS Glob Public Health
Vazquez Guillamet LJ, Valencia J, Ryan P, Matarranz M, Cuevas-Tascón G, Del-Olmo-Morales MA, Laguna L, Casanueva N, Viladomiu C, Matthews LT, Lazarus JV, Chevance G.   +11 more
europepmc   +1 more source

Controlling Symptoms versus Minimizing Negative Treatment Impact: A Grounded Theory Study of Heterogeneity in Patient Preferences for Psoriasis Treatments. [PDF]

Patient Prefer Adherence
Szabo SM, Hawkins NS, Germeni E.
europepmc   +1 more source

The freebirth debate: Respecting autonomy while reflecting on our own practices. [PDF]

Acta Obstet Gynecol Scand
Gunnarsdóttir J, Hjartardóttir H.
europepmc   +1 more source

Primary Care Practitioners' Approaches to Deprescribing Opioids for Older Adults With Chronic Pain: A Qualitative Analysis. [PDF]

J Am Geriatr Soc
Wang BX, Lindenberg JH, Herzig SJ, Schonberg MA, Anderson TS.   +4 more
europepmc   +1 more source