Results 31 to 40 of about 1,302,837 (318)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Overcoming barriers and enabling artificial intelligence adoption in allied health clinical practice: A qualitative study

Digital Health
Background Artificial intelligence (AI) has the potential to revolutionise healthcare. If the implementation is successful it has the potential to improve healthcare outcomes for patients and organisations. Little is known about the perceptions of allied
Jane Hoffman, Rachel Wenke, Rebecca L Angus, Lucy Shinners, Brent Richards, Laetitia Hattingh   +5 more
doaj   +1 more source

An unusual case of invasive pleuritis and miliary Mycoplasma pneumonia during check‐point inhibitor therapy

Respirology Case Reports, 2021
A growing body of evidence suggests that check‐point inhibitors not only increase the overall risk of infections, but, due to an altered immune response, may also result in atypical manifestations.
Daniel Bird, Maninder Singh
doaj   +1 more source

Biomineralization of Gold: Biofilms on Bacterioform Gold

Science, 2006
Bacterial biofilms are associated with secondary gold grains from two sites in Australia. 16 S ribosomal DNA clones of the genus Ralstonia that bear 99% similarity to the bacterium Ralstonia metallidurans —shown to precipitate gold from aqueous gold(III) tetrachloride ...
Stephen L. Rogers, Stephen L. Rogers, Derry McPhail, Derry McPhail, Frank Reith, Daryl Webb   +5 more
openaire   +4 more sources

Excited States of Gold(I) Compounds, Luminescence and Gold‐Gold Bonding [PDF]

Metal-Based Drugs, 1994
It has long been established by Khan that the superoxide anion, , generates singlet oxygen, , during dismutation. Auranofin, gold‐phosphine thiols, β‐Carotene, and metal‐sulfur compounds can rapidly quench singlet O2. The quenching of the , which exists at 7752 cm-1 above the ground state triplet, may be due to the direct interaction of the singlet O2 ...
John P. Fackler, Zerihun Assefa, Jennifer M. Forward, Richard J. Staples   +3 more
openaire   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Long term outcomes of open reduction internal fixation versus external fixation of distal radius fractures: A meta-analysis

Orthopedic Reviews, 2019
Distal radius fractures are among the most common fractures encountered in the clinical setting. Of these common fractures, it has been said that up to 60% are intraarticular in nature.
Conor Gouk, Shu-Kay Ng, Matthew Knight, Randy Bindra, Michael Thomas   +4 more
doaj   +1 more source

The Kumtor gold deposit in the Middle Tien Shan, Kyrgyzstan, and the application of 3-D modeling in Seequent’s Leapfrog Geo software for the geological exploration

Руды и металлы, 2023
The Kumtor deposit is one of the largest gold deposits in the Tien Shan. The ore zones are localized in rocks of the black shale formation, in an amagmatic gently dipping structure.
Shevkunov A. G., Kornitsky A. I., Bashkirov A. P., Aidarkulov T. N.   +3 more
doaj   +1 more source