Results 41 to 50 of about 3,725,501 (290)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effectiveness of combining geotechnologies when mining gold

Известия Томского политехнического университета: Инжиниринг георесурсов
Aim. To simulate combination of gold mining technologies to increase the efficiency of its opening and optimize costs. The efficiency of metal extraction depends on a combination of the possibilities of extraction and enrichment technologies for metal ...
Vladimir I. Golik
doaj   +1 more source

Mineralogical features and particle-size distribution of refractory gold in technogenic tailings [PDF]

E3S Web of Conferences
This study evaluates the mineralogical and granulometric characteristics of technogenic waste from the tailings storage facility of Hydrometallurgical Plant No.
Khujakulov Nurmurod, Nasirova Nigora, Majidova Iroda, Mirzayev Bahovuddin   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Gold Extraction to Ferrosilicium, Production of Foam Silicate from Processing Tails of the Olimpiada Mining and Processing Complex Gold Processing Plant (Russia, Krasnoyarsk Territory) [PDF]

, 2019
The paper describes the studies of processing tails of the Olimpiada Mining and Processing Complex with the methods of chemical, mineralogical, electronic microscope, deep reductive melting with division of the melt into a silicate and metal parts. It is demonstrated that 85% of the processing tails consist of the oxides: SiO2, CaO, Al2O3, Fe2O3, H2O ...
A. Sazonov, V. Pavlov, S. Silyanov, E. Zvyagina   +3 more
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Dressability of Old Gold-Bearing Tailings by Flotation

, 2020
Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.The research results on floatability of old gold-bearing tailings are presented.
Baksheeva, I. I., Bragin, V. I., Kondrat’Eva, A. A., Burdakova, E. A., Plotnikova, A. A.   +4 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Cultivation of vetiver in saline tailings contaminated with arsenic under phosphorus doses

Revista Brasileira de Engenharia Agrícola e Ambiental
The processing of gold ores exploited in Paracatu, MG, generates tailings that are challenging for revegetation, mainly because of the high content of arsenic and salinity.
Lorena A. de O. P. Guimarães, Luiz E. Dias, Igor R. de Assis, Amanda L. Cordeiro   +3 more
doaj   +1 more source

Forecasting mass and metallurgical balance at a gold processing plant using modern multivariate statistics

REM: International Engineering Journal, 2020
Knowing the quantity and the quality of products and tailings generated by a beneficiation plant, even before ore processing, can make the mining operations more sustainable, more profitable, and safer. To forecast these values, it is necessary to submit
Fernanda Gontijo Fernandes Niquini, João Felipe Coimbra Leite Costa   +1 more
doaj   +1 more source