Results 71 to 80 of about 6,539,865 (341)

Sequencing: Not Always the “Gold Standard” [PDF]

Clinical Chemistry, 2004
For the detection of point mutations (or variant alleles), PCR followed by restriction fragment length polymorphism (RFLP) detection is widely used and is probably one of the simplest methods for detection of known mutations. This method depends on the fact that the mutation of interest disrupts a recognition sequence for a restriction enzyme.
Ilse P. van der Heiden, Jan Lindemans, Ron H.N. van Schaik, Marloes van der Werf   +3 more
openaire   +3 more sources

ETDRS Grading of Diabetic Retinopathy: Still the Gold Standard?

Ophthalmic Research, 2019
This article aims to provide a narrative history of the evolution, modification, and legacy of the Early Treatment Diabetic Retinopathy Study classification system.
Sharon D. Solomon, M. Goldberg
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Validity and Reliability of Wearable Sensors for Joint Angle Estimation: A Systematic Review

Sensors, 2019
Motion capture systems are recognized as the gold standard for joint angle calculation. However, studies using these systems are restricted to laboratory settings for technical reasons, which may lead to findings that are not representative of real-life ...
Isabelle Poitras, Frédérique Dupuis, Mathieu Bielmann, Alexandre Campeau-Lecours, Catherine Mercier, Laurent J. Bouyer, Jean-Sébastien Roy   +6 more
doaj   +1 more source

A Private Bank as Lender of Last Resort Under the Classical Gold Standard.

Jahrbuch für Wirtschaftsgeschichte, 2022
The author argues that the idea, that the Bank of England accepted Walter Bagehot's recommendations from around the 1870s onwards and adopted the role of lender of last resort for the British financial markets, is a misconception.
Ziegler Dieter
doaj   +1 more source

Gibson's Paradox and the Gold Standard [PDF]

Journal of Political Economy, 1985
This paper contributes a new element to the explanation of the Gibson paradox, the puzzling correlation between interest rates and the price level seen during the gold standard period. A shock that raises the underlying real rate of return in the economy reduces the equilibrium relative price of gold and, with the nominal price of gold pegged by the ...
Robert B. Barsky, Lawrence H. Summers
openaire   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Evaluation of the performance of three serological tests for diagnosis of Leishmania infantum infection in dogs using latent class analysis

Revista Brasileira de Parasitologia Veterinária, 2020
Canine leishmaniasis (CanL) is a disease caused by Leishmania infantum. Serological methods are the most common diagnostic techniques used for the diagnosis of the CanL. The objective of our study was to estimate the sensitivity and specificity of one in-
Asier Basurco, Alda Natale, Katia Capello, Antonio Fernández, María Teresa Verde, Ana González, Andrés Yzuel, Jacobo Giner, Sergio Villanueva-Saz   +8 more
doaj   +1 more source

Changing the gold standard [PDF]

Nature Chemistry, 2019
Gold — long presumed to be an inert metal — has been increasingly shaking this image over the past couple of decades, mostly through electrophilic behaviour. Now, a two-coordinate gold complex has been shown to exhibit nucleophilic reactivity, with the insertion of CO2 into its polarized Auδ−–Alδ+ bond.
openaire   +3 more sources

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source