Results 71 to 80 of about 2,274,619 (355)
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Cukurova Medical Journal, 2021 Amaç: Tanı testleri, hasta ve sağlıklı bireylerin oluşturduğu heterojen bir kitlede bireyin gerçek durumunu ortaya çıkarmak amacıyla kullanılır. Bu çalışmada, altın standart test yokluğunda, Bayesci yaklaşım ile ilgilenilen tanı testine ait doğruluk ...
Yusuf Kemal Arslan
doaj +1 more source
Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis
Molecular Oncology, EarlyView.Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch +11 more
wiley +1 more source
Gold Standard for Expert Ranking: A Survey on the XWiki Dataset [PDF]
arXiv, 2016 We are designing an automated technique to find and recommend experts for helping in Requirements Engineering tasks, which can be done by ranking the available people by level of expertise. For evaluating the correctness of the rankings produced by the automated technique, we want to compare them to a gold standard. In this work, we ask external people
arxiv
Further Developments in Gold-stud Bump Bonding [PDF]
, 2011 As silicon detectors in high energy physics experiments require increasingly complex assembly procedures, the availability of a wide variety of interconnect technologies provides more options for overcoming obstacles in generic R&D. Gold ball bonding has been a staple in the interconnect industry due to its ease of use and reliability.
arxiv +1 more source
Adjusting for misclassification of an exposure in an individual participant data meta-analysis [PDF]
arXiv, 2021 A common problem in the analysis of multiple data sources, including individual participant data meta-analysis (IPD-MA), is the misclassification of binary variables. Misclassification may lead to biased estimates of model parameters, even when the misclassification is entirely random.
arxiv
Changing the gold standard [PDF]
Nature Chemistry, 2019 Gold — long presumed to be an inert metal — has been increasingly shaking this image over the past couple of decades, mostly through electrophilic behaviour. Now, a two-coordinate gold complex has been shown to exhibit nucleophilic reactivity, with the insertion of CO2 into its polarized Auδ−–Alδ+ bond.
openaire +3 more sources
Molecular Oncology, EarlyView.FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana +17 more
wiley +1 more source
Exposing ambiguities in a relation-extraction gold standard with crowdsourcing [PDF]
arXiv, 2015 Semantic relation extraction is one of the frontiers of biomedical natural language processing research. Gold standards are key tools for advancing this research. It is challenging to generate these standards because of the high cost of expert time and the difficulty in establishing agreement between annotators. We implemented and evaluated a microtask
arxiv