Results 71 to 80 of about 8,041,713 (397)
Sequencing: Not Always the “Gold Standard” [PDF]
Clinical Chemistry, 2004 For the detection of point mutations (or variant alleles), PCR followed by restriction fragment length polymorphism (RFLP) detection is widely used and is probably one of the simplest methods for detection of known mutations. This method depends on the fact that the mutation of interest disrupts a recognition sequence for a restriction enzyme.
Ilse P. van der Heiden +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
PathogensThe diagnosis of canine leishmaniasis (CanL) still represents a challenge due to the variable clinical manifestations and the large number of asymptomatic dogs.
Henrique C. Teixeira +11 more
doaj +1 more source
Dual energy X‐ray absorptiometry: gold standard for muscle mass?
Journal of Cachexia, Sarcopenia and Muscle, 2018 Since the late 90s, dual energy X-ray absorptiometry (DXA) has been validated against so-called gold standards for body composition (BC) by comparison to chemical analysis, dissection, and anatomy-based imaging methods (CT or MRI).
A. Scafoglieri, J. Clarys
semanticscholar +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
ETDRS Grading of Diabetic Retinopathy: Still the Gold Standard?
Ophthalmic Research, 2019 This article aims to provide a narrative history of the evolution, modification, and legacy of the Early Treatment Diabetic Retinopathy Study classification system.
Sharon D. Solomon, M. Goldberg
semanticscholar +1 more source
How the Gold Standard Functioned in Portugal: An Analysis of Some Macroeconomic Aspects [PDF]
The purpose of this study is to improve understanding of the gold standard period in Portugal through comparison with other monetary systems that were operated afterwards.
António Portugal Duarte +1 more
core +3 more sources
An Evaluation of Multiple Query Representations for the Relevance Judgments used to Build a Biomedical Test Collection [PDF]
Healthcare Informatics Research, 2012 ObjectivesThe purpose of this study is to validate a method that uses multiple queries to create a set of relevance judgments used to indicate which documents are pertinent to each query when forming a biomedical test collection.MethodsThe aspect query ...
Borim Ryu, Jinwook Choi
doaj +1 more source
Changing the gold standard [PDF]
Nature Chemistry, 2019 Gold — long presumed to be an inert metal — has been increasingly shaking this image over the past couple of decades, mostly through electrophilic behaviour. Now, a two-coordinate gold complex has been shown to exhibit nucleophilic reactivity, with the insertion of CO2 into its polarized Auδ−–Alδ+ bond.
openaire +3 more sources