Results 71 to 80 of about 1,374,879 (330)

The neuronal Golgi in neural circuit formation and reorganization

Frontiers in Neural Circuits
The Golgi apparatus is a central hub in the intracellular secretory pathway. By positioning in the specific intracellular region and transporting materials to spatially restricted compartments, the Golgi apparatus contributes to the cell polarity ...
Naoki Nakagawa, Naoki Nakagawa
doaj   +1 more source

Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparum.

PLoS ONE, 2014
During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite's plasma membrane.
Priscilla Krai, Seema Dalal, Michael Klemba   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells

Molecular Systems Biology, 2012
The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus.
Joanne Chia, Germaine Goh, Victor Racine, Susanne Ng, Pankaj Kumar, Frederic Bard   +5 more
doaj   +1 more source

Subcellular localization of microsomal triglyceride transfer protein

Journal of Lipid Research, 2003
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of apolipoprotein B-containing lipoproteins. Within the endoplasmic reticulum, it transfers lipid from the membrane to the forming lipoprotein.
Larry L. Swift, Mei-Ying Zhu, Bharati Kakkad, Aneta Jovanovska, M. Diana Neely, Klara Valyi-Nagy, Richard L. Roberts, David E. Ong, W. Gray Jerome   +8 more
doaj   +1 more source

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]

, 2013
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang, Ackema, K. B., Jachen A Solinger, Karin B Ackema, Ursula Sauder, Solinger, J. A., Karin B. Ackema, Jachen A. Solinger (254344), Jachen A. Solinger, Karin B. Ackema (423507), Ursula Sauder (250540), Spang, A., Anne Spang (205738), Sauder, U.   +13 more
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation

Experimental Eye Research, 2018
The formation and life‐long growth of the ocular lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To achieve their mature structure and transparent function, newly formed lens fiber cells undergo a series of ...
Lisa A Brennan, Rebecca S McGreal-Estrada, C. Logan, A. Cvekl, A. Menko, M. Kantorow   +5 more
semanticscholar   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Golgi pH homeostasis stabilizes the lysosomal membrane through N -glycosylation of membrane proteins

Life Science Alliance
Golgi pH imbalance ( Gphr deficiency) disrupts lysosomal membrane protein glycosylation, compromising lysosomal membrane stability, highlighting the critical role of the Golgi apparatus.
Yu-shin Sou, Junji Yamaguchi, Keisuke Masuda, Yasuo Uchiyama, Yusuke Maeda, Masato Koike   +5 more
doaj   +1 more source