Results 51 to 60 of about 1,085,148 (332)

Golgi Dynamics: The Morphology of the Mammalian Golgi Apparatus in Health and Disease

Front. Cell Dev. Biol., 2019
In vertebrate cells the Golgi consists of individual stacks fused together into a compact ribbon structure. The function of the ribbon structure of the Golgi has only begun to be appreciated (De Matteis et al., 2008; Gosavi and Gleeson, 2017; Wei and ...
Christian Makhoul, Prajakta Gosavi, P. Gleeson   +2 more
semanticscholar   +1 more source

Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner

Cell Communication and Signaling, 2023
Background Lung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H2O2 is one of the virulence factors of Streptococcus pneumoniae. The Golgi apparatus is essential for the inflammatory response
Björn Klabunde, André Wesener, Wilhelm Bertrams, Stephan Ringshandl, Luke D. Halder, Evelyn Vollmeister, Bernd Schmeck, Birke J. Benedikter   +7 more
doaj   +1 more source

Associating bovine herpesvirus 1 envelope glycoprotein gD with activated phospho-PLC-γ1(S1248)

Microbiology Spectrum, 2023
Phospholipase C gamma 1 (PLC-γ1) may locate at distinct subcellular locations, such as cytosol, plasma membrane, and nucleus for varied biological functions.
Chang Liu, Weifeng Yuan, Hao Yang, Junqing Ni, Linke Tang, Heci Zhao, Donna Neumann, Xiuyan Ding, Liqian Zhu   +8 more
doaj   +1 more source

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]

, 2006
Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Adam, Alonso, Araibi, Ashrafi, Ashrafi, Auvinen, Bubb, Chang, Cohen, Conrad, Cresswell, Dickie, Disbrow, Faccini, Fackler, Frazer, Goldstein, Hwang, Kasper, Kell, Lu, Marchetti, Marchetti, Rodriguez, Straight, Straight, Suprynowicz, Thomsen, Williams, Williams, zur Hausen   +30 more
core   +1 more source

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle‐free zone formation

Experimental Eye Research, 2018
The formation and life‐long growth of the ocular lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To achieve their mature structure and transparent function, newly formed lens fiber cells undergo a series of ...
L. Brennan, Rebecca S McGreal-Estrada, C. Logan, A. Cvekl, S. Menko, M. Kantorow   +5 more
semanticscholar   +1 more source

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

eLife, 2016
The membrane-bound transcription factor ATF6α is activated by proteolysis during endoplasmic reticulum (ER) stress. ATF6α target genes encode foldases, chaperones, and lipid biosynthesis enzymes that increase protein-folding capacity in response to ...
Ciara M. Gallagher, P. Walter
semanticscholar   +1 more source

The neuronal Golgi in neural circuit formation and reorganization

Frontiers in Neural Circuits
The Golgi apparatus is a central hub in the intracellular secretory pathway. By positioning in the specific intracellular region and transporting materials to spatially restricted compartments, the Golgi apparatus contributes to the cell polarity ...
Naoki Nakagawa, Naoki Nakagawa
doaj   +1 more source

RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells

Molecular Systems Biology, 2012
The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus.
Joanne Chia, Germaine Goh, Victor Racine, Susanne Ng, Pankaj Kumar, Frederic Bard   +5 more
doaj   +1 more source

Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparum.

PLoS ONE, 2014
During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite's plasma membrane.
Priscilla Krai, Seema Dalal, Michael Klemba   +2 more
doaj   +1 more source

The Golgi apparatus: 100 years of progress and controversy. [PDF]

, 1998
Research on the Golgi apparatus has resulted in major advances in understanding its structure and functions, but many important questions remain unanswered.
Farquhar, MG, Palade, GE
core