Results 61 to 70 of about 1,085,148 (332)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Subcellular localization of microsomal triglyceride transfer protein

Journal of Lipid Research, 2003
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of apolipoprotein B-containing lipoproteins. Within the endoplasmic reticulum, it transfers lipid from the membrane to the forming lipoprotein.
Larry L. Swift, Mei-Ying Zhu, Bharati Kakkad, Aneta Jovanovska, M. Diana Neely, Klara Valyi-Nagy, Richard L. Roberts, David E. Ong, W. Gray Jerome   +8 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Ultrastructure of calcareous dinophytes (Thoracosphaeraceae, Peridiniales) with a focus on vacuolar crystal-like particles. [PDF]

, 2013
Biomineralization in calcareous dinophytes (Thoracosphaeracaea, Peridiniales) takes place in coccoid cells and is presently poorly understood. Vacuolar crystal-like particles as well as collection sites within the prospective calcareous shell may play a ...
Gottschling, Marc, Kaulbars, Freya, Keupp, Helmut, Tischendorf, Gilbert, Zinssmeister, Carmen   +4 more
core   +7 more sources

Loss of Arabidopsis β-COP Function Affects Golgi Structure, Plant Growth and Tolerance to Salt Stress

Frontiers in Plant Science, 2020
The early secretory pathway involves bidirectional transport between the endoplasmic reticulum (ER) and the Golgi apparatus and is mediated by coat protein complex I (COPI)-coated and coat protein complex II (COPII)-coated vesicles.
Judit Sánchez-Simarro, César Bernat-Silvestre, Fátima Gimeno-Ferrer, Pilar Selvi-Martínez, Javier Montero-Pau, Fernando Aniento, María Jesús Marcote   +6 more
doaj   +1 more source

Intracellular localization of the BCL-2 family member BOK and functional implications [PDF]

, 2013
The pro-apoptotic BCL-2 family member BOK is widely expressed and resembles the multi-BH domain proteins BAX and BAK based on its amino acid sequence.
Bachmann, Daniel, Echeverry, Nohemy, Kaufmann, Thomas, Ke, Francine, Simon, Hans-Uwe, Strasser, Andreas   +5 more
core   +1 more source

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

BMC Biology, 2016
After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation.
Marie Pourcelot, Naima Zemirli, Leandro Silva Da Costa, R. Loyant, D. Garcin, D. Vitour, Ivana Munitic, A. Vazquez, D. Arnoult   +8 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Golgi pH homeostasis stabilizes the lysosomal membrane through N -glycosylation of membrane proteins

Life Science Alliance
Golgi pH imbalance ( Gphr deficiency) disrupts lysosomal membrane protein glycosylation, compromising lysosomal membrane stability, highlighting the critical role of the Golgi apparatus.
Yu-shin Sou, Junji Yamaguchi, Keisuke Masuda, Yasuo Uchiyama, Yusuke Maeda, Masato Koike   +5 more
doaj   +1 more source