Results 91 to 100 of about 20,213 (210)

Dietary L‐Tyrosine Sustains Egg Production and Quality by Modulating Promoter CpG Methylation, Gene Expression, and Hormone Profiles in Reproductive Signalling Pathways of Aged Laying Hens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Managing prolactin (PRL)‐mediated reproductive suppression is critical for maintaining egg production in commercial laying hens. L‐tyrosine (TYR), a precursor of dopamine (DA), may counteract age‐related reproductive decline by suppressing PRL, thereby sustaining productivity and egg quality in late‐phase laying hens.
Hasan Hüseyin İpçak
wiley   +1 more source

A Systematic Review and Meta‐Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia

Journal of Sleep Research, EarlyView.
ABSTRACT Mounting evidence shows sex‐based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep
Nyissa A. Walsh, Emma‐Maria Phillips, Arsenio Páez, Nathan E. Cross, Thien Thanh Dang‐Vu, Aurore A. Perrault   +5 more
wiley   +1 more source

Vertebrate endocrine disruptors induce sex-reversal in blue mussels

Scientific Reports
Mollusks are the second most diverse animal phylum, yet little is known about their endocrinology or how they respond to endocrine disrupting compound (EDC) pollution. Characteristic effects of endocrine disruption are reproductive impairment, skewed sex
K. Garrett Evensen, Emily Rusin, William E. Robinson, Claire L. Price, Steven L. Kelly, David C. Lamb, Jared V. Goldstone, Helen C. Poynton   +7 more
doaj   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Endocrine and androgenic response to altitude training in professional cyclists

The Journal of Physiology, EarlyView.
Abstract figure legend Steroidal and endocrine variables are altered during altitude training. Abstract This study investigated endocrine and steroidal blood markers in 31 male elite cyclists monitored over 7 weeks, including a 3 week altitude training camp either at 2050 m (n = 19) or 3000 m (n = 12).
Raphael Faiss, Bastien Krumm, Claes Cubel, Magnus Bak Klaris, Lasse Vestli Baekken, Yvette Dehnes, Jenna Goodrum, Geoff Miller, James Spragg, Martin Faulhaber, Francesco Botrè, Carsten Lundby   +11 more
wiley   +1 more source

Effects of empagliflozin on reproductive system in men without diabetes

Scientific Reports
Sodium-glucose cotransporter (SGLT) 2 inhibition is a well-known target for the treatment of type 2 diabetes, renal disease and chronic heart failure. The protein SGLT2 is encoded by SLC5A2 (Solute Carrier Family 5 Member 2), which is highly expressed in
Christophe Kosinski, Georgios E. Papadakis, Olivier Salamin, Tiia Kuuranne, Raul Nicoli, Nelly Pitteloud, Anne Zanchi   +6 more
doaj   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, EarlyView.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level

Communications Biology
Fish sex is largely influenced by steroid hormones, especially sex hormones. Here, we established a steroid hormone-free genetic model by mutation of cyp11a1 in Nile tilapia, which was confirmed by EIA assay.
Hesheng Xiao, Leihui Wang, Shuo Yan, He Ma, Zhen Xu, Feilong Wang, Jingrong Wang, Wenjing Tao, Deshou Wang   +8 more
doaj   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, Volume 105, Issue 3, Page 271-284, September 2026.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source