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Bilateral Gonadoblastoma in a 12‐Year‐Old Girl 4 Years After Wilms' Tumor: A Rare Pediatric Case [PDF]

Clinical Case Reports
This case of a 12‐year‐old patient who developed bilateral gonadoblastoma 4 years after treatment for Wilms tumor highlights the importance of rigorous, risk‐adapted long‐term surveillance and careful evaluation of incidental gonadal findings, even in ...
Ahmed Quraish, Hasan Khouli, Yousef Daraghmeh, Sultan Mosleh, Samer Bustame   +4 more
doaj   +3 more sources

Co‐Occurrence of Ovarian Dysgerminoma‐Inducing Gonadoblastoma and Two Distinct Mammary Carcinomas in a Dog: A Case Report and Review of the Literature [PDF]

Veterinary Medicine and Science
Gonadoblastoma (GB) is an extremely rare mixed gonadal neoplasm, encountered in animals as well as humans. The tumour is typically reported in dysgenetic gonads of those suffering from disorders of sex development and bearing the Y chromosome.
Diba Golchin, Farhang Sasani, Saeed Farzad‐Mohajeri, Mohsen Tovhidifar, Iradj Ashrafi Tamai   +4 more
doaj   +3 more sources

Balancing oncologic risk and fertility potential: a single-center study on Turner syndrome patients with Y chromosome material [PDF]

Frontiers in Endocrinology
IntroductionTurner Syndrome (TS) is a chromosomal disorder characterized by partial or complete monosomy of the X chromosome. Approximately 5–10% of patients with TS harbor Y chromosome material, which is associated with an increased risk of ...
Xia Shuai, Zhibing Guo, Dongguang Zhang, Hui Huang, Ka Chen, Yu Yang, Qinghua Hu   +6 more
doaj   +2 more sources

Gonadoblastoma with Dysgerminoma in a Virilized Adolescent with Karyotype 46,XX: A Case Report and Review of the Literature [PDF]

JCRPE
Gonadoblastoma is a rare gonadal tumor composed of sex cord cells and primitive germ cells. While the majority of gonadoblastomas are found in individuals with 46,XY gonadal dysgenesis, they are also rarely seen in patients with a 46,XX karyotype.
Tugce Kandemir, Esin Karakilic Ozturan, Ozlem Dural, Ayca Dilruba Aslanger, Elif Inan Balci, Aysel Bayram, Semen Onder, Asli Derya Kardelen, Melek Yildiz, Sukran Poyrazoglu, Firdevs Bas, Feyza Darendeliler   +11 more
doaj   +2 more sources

Male hermaphroditism with rare malignant transformation of gonadal organs: a case report [PDF]

Discover Oncology
A 27-year-old man was admitted to the hospital after a year of marriage due to infertility. During laparoscopic exploratory surgery, the presence of a retrovesical uterus was clearly observed, and the gonadal organs were visible on both sides.
Zhengyu He, Zhiyuan Li, Mei Chen
doaj   +2 more sources

Mixed Ovarian Dissecting Gonadoblastoma Coexisting with Dysgerminoma, Trophoblastic Tumor, and Leydig Cell Tumor in a Phenotypically Normal 46, XX Female: A Case Report [PDF]

International Journal of Women's Health
Wenxian Xu, Ketan Chu, Yizhou Huang, Yibing Lan, Jianhong ZhouDepartment of Gynecology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Jianhong Zhou, Department of Gynecology ...
Xu W, Chu K, Huang Y, Lan Y, Zhou J
doaj   +2 more sources

Rare presentations of Swyer syndrome in a 13.5-year-old female; a case report and literature review [PDF]

BMC Pediatrics
Background Swyer syndrome (SS), or 46, XY pure gonadal dysgenesis, is a rare disorder of sex development. It typically presents with primary amenorrhea and an absence of secondary sexual characteristics.
Alireza Sadeghi, Romina Rezaei, Zahra Razavi, Amir Mohammad Salehi, Arash Dehghan   +4 more
doaj   +2 more sources

Histomorphological Spectrum of Gonadal and Extragonadal Germ Cell Tumours at a Tertiary Cancer Centre in Southern Rajasthan, India [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Germ Cell Tumours (GCT) are heterogenous tumours believed to arise from primordial germ cells. The GCT predominantly affects gonads (testis and ovary) and also involves extragonadal sites, characteristically locations along midline of ...
Tarang Patel, Swati Jindal, Swati Jindal, Aruna Panchariya   +3 more
doaj   +1 more source

Exonic WT1 pathogenic variants in 46,XY DSD associated with gonadoblastoma

Endocrine Connections, 2021
Objective: The literature regarding gonadoblastoma risk in exonic Wilms’ tumor suppressor gene (WT1) pathogenic variants is sparse. The aim of this study is to describe the phenotypic and genotypic characteristics of Asian–Indian patients with WT1 ...
Sneha Arya, Sandeep Kumar, Anurag R Lila, Vijaya Sarathi, Saba Samad Memon, Rohit Barnabas, Hemangini Thakkar, Virendra A Patil, Nalini S Shah, Tushar R Bandgar   +9 more
doaj   +1 more source

Bilateral Ovarian Germ Cell Tumor in a 46,XX Female with Nijmegen Breakage Syndrome and Hypergonadotropic Hypogonadism

JCRPE, 2022
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disease, affecting mainly patients of Slavic origin. It is caused by a defect in the NBN gene, resulting in defective nibrin protein formation.
Malgorzata A. Krawczyk, Malgorzata Styczewska, Dorota Birkholz-Walerzak, Mariola Iliszko, Beata S. Lipska-Zietkiewicz, Wojciech Kosiak, Ninela Irga-Jaworska, Ewa Izycka-Swieszewska, Ewa Bien   +8 more
doaj   +1 more source