Results 111 to 120 of about 98,362 (270)

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin

, 2013
There remains a critical need for new therapeutics that promote wound healing in patients suffering from chronic skin wounds. This is, in part, due to a shortage of simple, physiologically and clinically relevant test systems for investigating candidate ...
Paredes Roberto, Matthias Augustin, Jennifer E Kloepper, Amaya, Enrique; id_orcid, Roberto Paredes (452874), Pattwell David M., Natalia T. Meier (452870), Enrique Amaya, Matthias Augustin (452876), Haslam Iain S., Augustin Matthias, Paus Ralf, Hardman, Matthew J, Kloepper, Jennifer E, Paus, Ralf, Sebastian Debus, Pattwell, David M., Wolfgang Funk, Matthew J Hardman, Wolfgang Funk (405807), Kloepper Jennifer E., Meier Natalia T., Matthew J. Hardman (452878), Amaya, Enrique, Zhang, Guo You, Amaya Enrique, Debus, Sebastian, Zhang Guo-You, Vladimir Emelianov (452873), Jennifer E. Kloepper (452877), Paredes, Roberto, Emelianov Vladimir, Guo-You Zhang, Sebastian Debus (452875), Hardman Matthew J., Haslam, Iain S., Funk Wolfgang, Hardman, Matthew J., Augustin, Matthias, Pattwell, David M, Kloepper, Jennifer E., Haslam, Iain S, Enrique Amaya (31703), Ralf Paus (261703), Emelianov, Vladimir, Haslam, Iain, Zhang, Guo-You, Natalia T Meier, Debus Sebastian, Meier, Natalia T., Vladimir Emelianov, Iain S Haslam, Roberto Paredes, David M. Pattwell (452872), Ralf Paus, Meier, Natalia T, Guo-You Zhang (397743), Funk, Wolfgang, Iain S. Haslam (452871), David M Pattwell   +59 more
core   +1 more source

Dynamics of Body Composition and Metabolic Risk in Adolescents With Obesity Under GLP‐1 Receptor Agonist Therapy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To explore changes in body composition in adolescents with obesity treated with glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) and their association with metabolic syndrome (MetS) components. Methods This real‐world retrospective study included adolescents (12–18 years) with obesity who received multidisciplinary lifestyle‐based ...
Adar Lopez, Liat Perl, Eyal Cohen‐Sela, Ophir Borger, Yael Issan, Hagar Interator, Erez Azoulay, Hadar Moran‐Lev, Ronit Lubetzky, Shira Zelber‐Sagi, Yael Lebenthal, Avivit Brener   +11 more
wiley   +1 more source

Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels

JACC: Basic to Translational Science
Summary: Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ−
Wilhelmina C.M. Duivenvoorden, MSc PhD, David Margel, MD, PhD, Vishal Subramony Gayathri, MSc, Emmanuelle Duceppe, MD, PhD, Sadiya Yousef, BSc, Magda Naeim, PhD, Mohammad Khajehei, MSc, Sarah Hopmans, MSc, Snezana Popovic, MD, Yaara Ber, MSc, Diane Heels-Ansdell, MSc, Philip J. Devereaux, MD, PhD, Jehonathan H. Pinthus, MD, PhD   +12 more
doaj   +1 more source

Structure and function of sea urchin neuropeptides

, 2010
PhDThe subject of this thesis is the identification and functional characterization of sea urchin neuropeptides. Neuropeptides are important mediators of neural signalling in all known animals with a nervous system, including bilaterians, ctenophorans ...
Rowe, Matthew Lyndon
core  

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man.

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

In vitro steroid production by follicles of frog Rana esculenta: mammalian gonadotropin-releasing hormone effects.

, 1991
The effects of mammalian gonadotropin-releasing hormone on ovarian release of progesterone, androgens and estradiol-17 beta were studied in vitro by a superfusion system carried out on follicles of adult female Rana esculenta, collected at different ...
GOBBETTI, Anna, ZERANI, Massimo, Polzonetti Magni A.   +2 more
core   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Three‐Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue‐Clearing Imaging

Cell Proliferation, EarlyView.
Our study employed a modified tissue‐clearing method combined with deep imaging for 3D reconstruction of ovarian endometriosis (OEM) lesions, revealing its morphological polymorphism at tissue and cellular levels. Besides, vessels preferentially clustered around the ectopic epithelium, with their distribution pattern strongly linked to the location of ...
Fanyuan Sun, Shuzhen Wang, Jinyan Zhao, Jinhua Leng, Xili Zhu, Chongdong Liu, Jing Chen, Jinming Guo, Bangjing Jiang, Haihe Zhou, Zhuoying Li, Hua Li, Menghui Li, Yongcun Qu   +13 more
wiley   +1 more source