Results 1 to 10 of about 3,663 (130)

LHRH-Conjugated Magnetite Nanoparticles and Nanorods as Magnetic Resonance Imaging Contrast Agents for Targeting Triple-Negative Breast Cancer [PDF]

Journal of Functional Biomaterials
This paper presents the results of an experimental study on the effects of magnetite nanoparticle (MNP) shape on magnetic resonance imaging (MRI) of triple-negative breast cancer (TNBC) xenograft tissues. T2-weighted MRI scans using spherical shaped MNPs
Chukwudi C. Ezeala, John D. Obayemi, Ali A. Salifu, Theresa Ezenwafor, Yiporo Danyuo, Maria Chinyerem Onyekanne, Stanley C. Eluu, Toyin Aina, Josephine Oparah, Precious O. Etinosa, Olushola S. Odusanya, Winston O. Soboyejo   +11 more
doaj   +2 more sources

Multifunctional Lipid-Based Nanoparticles for Codelivery of Anticancer Drugs and siRNA for Treatment of Non-Small Cell Lung Cancer with Different Level of Resistance and EGFR Mutations

Pharmaceutics, 2021
Resistance to chemotherapy, enhanced proliferation, invasion, angiogenesis, and metastasis (RPIAM) represent major obstacles that limit the efficacy of cancer treatment especially in advanced stages of cancer.
Joydeb Majumder, Tamara Minko
doaj   +1 more source

Effect of the pineal gland and melatonin on dopamine release from perifused hypothalamus of mature female carp during spawning and winter regression [PDF]

Acta Ichthyologica et Piscatoria, 2005
Background. Melatonin regulates various physiological and neuroendocrinological processes that occur rhythmically, and stimulates or inhibits endocrine activity of various body glands. This acts on the hypothalamic-pituitary-gonadal axis by synchronizing
W. Popek, E. Łuszczek-Trojnar, E. Drąg-Kozak, D. Fortuna-Wrońska, P. Epler   +4 more
doaj   +3 more sources

Immunohistochemical expression of receptors for luteinizing hormone-releasing hormone (LHRHR) in muscle-invasive Urothelial carcinoma of urinary bladder: a potential predictive marker for targeted cytotoxic LHRH hybrid analogs

Surgical and Experimental Pathology, 2020
Background Recurrent disease following failed chemotherapy for muscle-invasive urothelial carcinoma (UC) has no universally accepted treatment guidelines.
Saba Yasir, Gustavo Fernandez-Castro, Numra Aslam Bajwa, Norman Block, Andrew Schally, Richard Cote, Merce Jorda   +6 more
doaj   +1 more source

Ultrasound-Targeted Microbubble Destruction-Mediated Inhibition of Livin Expression Accelerates Ovarian Cancer Cell Apoptosis

Genetics Research, 2021
Objective. Ultrasound-targeted microbubble destruction (UTMD) technique has recently been developed as a nonviral delivery of gene therapy. This study aimed at investigating the survival and apoptosis of ovarian cancer cell line OVCA-433 by inhibiting ...
Xiaolin Xu, Shuqin Yu, Xiaoyuan Liu, Ying Feng   +3 more
doaj   +1 more source

No supra-additive effects of goserelin and radiotherapy on clonogenic survival of prostate carcinoma cells in vitro

Radiation Oncology, 2007
Background Oncological results of radiotherapy for locally advanced prostate cancer (PC) are significantly improved by simultaneous application of LHRH analoga (e.g. goserelin).
Thelen Paul, Hille Andrea, Nitsche Mirko, Rave-Frank Margret, Grundker Carsten, Fister Stefanie, Schwarten Dag, Hermann Robert M, Schmidberger Heinz, Christiansen Hans   +9 more
doaj   +1 more source

HORMONE THERAPY WITH USAGE OF AGONISTS AND ANTAGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE IN PATIENTS WITH PROSTATE CANCER

Исследования и практика в медицине, 2015
Prostate cancer (PC) is one of the most actual problems of modern oncourology. Hormone therapy (HT) using medical castration is the main method of treatment of patients with metastatic PC.
K. M. Nyushko, A. A. Krasheninnikov, M. P. Golovaschenko, A. D. Kaprin   +3 more
doaj   +1 more source

The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons.

Folia Histochemica et Cytobiologica, 2006
Nitric oxide (NO) affects reproductive processes both at the level of the brain and reproductive tract and this review is focused on its role as an essential regulator of the hypothalamic control of reproduction. The data gathered indicate that glutamate
Jarosław Całka
doaj   +1 more source

99mTc-LHRH in tumor receptor imaging

Oncology Letters, 2017
Detection of gonadotropin-releasing hormone (GnRH) also known as luteinizing hormone-releasing hormone (LHRH) in the relevant tumor tissue and normal tissues and organs in vivo expression was investigated. To examine the method of direct radio labeling of LHRH by 99mTc with relatively high radiochemical purity and stability, screening the best labeling
Hao, Dawei, Sun, Lingfei, Hu, Xiang, Hao, Xiaowen   +3 more
openaire   +3 more sources

Locally Expressed LHRH Receptors Mediate the Oncostatic and Antimetastatic Activity of LHRH Agonists on Melanoma Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
Malignant melanoma is a tumor known for its uncontrollable growth and aggressive metastatic behavior. The mean survival time for patients with a metastatic melanoma is estimated to be less than 6 months, tumor cells being refractory to the conventional chemotherapy.
R.M. Moretti, M. Montagnani Marelli, J. C. Van Groeninghen, P. Limonta   +3 more
openaire   +3 more sources