Results 11 to 20 of about 3,979 (188)

AEZS-108: a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors [PDF]

Expert Opinion on Investigational Drugs, 2012
Receptors for the luteinizing hormone-releasing hormone [LHRH, also known as gonadotropin-releasing hormone (GnRH)] can be regarded as an ideal target for a personalized medicine approach in cancer therapy. LHRH receptors are expressed in about 80% of human endometrial and ovarian cancers, 86% of prostate cancer, and about 50% of breast cancers ...
Engel, Joerg B., Emons, Guenter, Pinski, Jacek, Schally, Andrew V.   +3 more
openaire   +4 more sources

Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats [PDF]

Proceedings of the National Academy of Sciences, 2001
The mechanisms through which luteinizing hormone (LH)-releasing hormone (LHRH) antagonists suppress pituitary gonadotroph functions and LHRH-receptor (LHRH-R) expression are incompletely understood. Consequently, we investigated the direct effect of LHRH antagonist cetrorelix in vitro on the expression of the ...
M, Kovacs, A V, Schally
openaire   +4 more sources

Expression of LHRH receptors in prostate cancer cells prior to therapy, following castration, or following treatment with LHRH agonists [PDF]

, 2009
5163 Background: In the treatment of advanced prostate cancer, the effects of luteinizing hormone releasing hormone (LHRH) agonists are mediated through the down-regulation of pituitary LHRH receptors, inhibiting the pituitary-gonadal axis.
Hawes, D, Engel, J, Brands, F, Xiong, S, Cai, J, Pinski, J, Liu, S, Schally, A. V, Gleave, M, Fazli, L, Cote, R   +10 more
core   +1 more source

Receptors for luteinizing hormone-releasing hormone (LHRH) in benign prostatic hyperplasia (BPH) as potential molecular targets for therapy with LHRH antagonist cetrorelix [PDF]

, 2010
The majority of men will develop symptoms of benign prostatic hyperplasia (BPH) after 70 years of age. Various studies indicate that antagonists of LHRH, such as cetrorelix, exert direct inhibitory effects on BPH mediated by specific LHRH receptors.
Balazs Dezso, Andrew V. Schally, Bernadett Rozsa, Melinda Mile, Norman L. Block, Toth, Gyorgy, Tibor Flasko, Rozsa, Bernadett, Block, Norman L, Flasko, Tibor, Halmos, Gabor, Gyorgy Toth, Schally, Andrew V, Nadji, Mehrdad, Mehrdad Nadji, Gabor Halmos, Dezso, Balazs, Mile, Melinda   +17 more
core   +1 more source

Triple-negative breast cancers express receptors for luteinizinghormone-releasing hormone (LHRH) and respond to LHRH antagonist cetrorelix withgrowth inhibition. [PDF]

, 2009
The aim of the present study was to evaluate the expression of receptors for luteinizing hormone-releasing hormone (LHRH) in human specimens of triple-negative breast cancers (TNBC).
Krishan A, Gaiser T, Hohla F, Szalontay L, Seitz S, Engel JB, Rick FG, Diedrich K, Köster F., Ortmann O, PAPADIA, ANDREA, Schally AV, Buchholz S, Brockhoff G   +13 more
core   +5 more sources

Receptors for luteinizing hormone releasing hormone (LHRH) expressed in human non-Hodgkin’s lymphomas can be targeted for therapy with the cytotoxic LHRH analogue AN-207 [PDF]

, 2005
We determined by immunohistochemistry the presence of LHRH receptors in surgical specimens of human non-Hodgkin’s lymphomas (NHL) and investigated the expression of LHRH receptors in two human NHL cell lines, RL and HT by RT-PCR, Western blot and ...
Andrew V. Schally, Attila Nagy, Gaiser, Timo, Keller, Gunhild, Baker, Benjamin, Halmos, Gabor, Gunhild Keller, Schally, Andrew V, Benjamin Baker, Gabor Halmos, Timo Gaiser, Jörg B. Engel, Engel, Jörg B, Nagy, Attila   +13 more
core   +1 more source

The participation of the muscarinic receptors in the preoptic-anterior hypothalamic areas in the regulation of ovulation depends on the ovary

Reproductive Biology and Endocrinology, 2016
Background Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle.
Adriana Espinosa-Valdez, Angélica Flores, Isabel Arrieta-Cruz, Mario Cárdenas, Roberto Chavira, Roberto Domínguez, María Esther Cruz   +6 more
doaj   +1 more source

Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer

Reproductive Biology and Endocrinology, 2003
The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary.
Emons Günter, Gründker Carsten
doaj   +1 more source

Receptors for luteinizing hormone-releasing hormone (LHRH) in Dunning R3327 prostate cancers and rat anterior pituitaries after treatment with a sustained delivery system of LHRH antagonist SB-75 [PDF]

, 1990
Membrane receptors for LHRH were evaluated in Dunning R3327 prostate cancers and rat anterior pituitaries. The receptors were characterized both in untreated animals and after in vivo treatment with microcapsules of the agonist D-Trp6-LHRH and a ...
Bokser, L, Korkut, E, Radulovic, S, Schally, A V, Srkalovic, G   +4 more
core   +1 more source

Involvement of Membrane Progestin Receptor Beta (mPRβ/Paqr8) in Sex Pheromone Progestin-Induced Expression of Luteinizing Hormone in the Pituitary of Male Chinese Black Sleeper (Bostrychus Sinensis)

Frontiers in Endocrinology, 2018
Our previous studies showed that 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) acted as a sex pheromone to induce reproductive success in Chinese black sleeper (Bostrychus sinensis), but its functional mechanism remains unclear.
Yu Ting Zhang, Wan Shu Hong, Dong Teng Liu, Heng Tong Qiu, Yong Zhu, Yong Zhu, Shi Xi Chen, Shi Xi Chen, Shi Xi Chen   +8 more
doaj   +1 more source