Results 21 to 30 of about 3,979 (188)

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C., Pepeu, G., Gratzl, M., Gamel-Didelon, Katia, Jung, H., Mayerhofer, Artur   +5 more
core   +1 more source

Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Cancer [PDF]

, 2006
This chapter discusses the development of agonists and antagonists of luteinizing hormone-releasing hormone (LHRH), also known as GnRH, and their clinical uses.
JORG ENGEL, ANDREW V. SCHALLY, Schally, Andrew V, Engel, Jorg   +3 more
core   +1 more source

Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125 [PDF]

, 2014
Background Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents.
Szakontay, Luca, Schally, Andrew Victor, Weber, Florian, Andrew Victor Schally, Inwald, Elizabeth C., Hohla, Florian, Elisabeth C Inwald, Rick, Ferenc G, Klinkhammer-Schalke, Monika, Seitz, Stephen, Buchholz, Stefan, Engel, Jorg Bernhard, Olaf Ortmann, Roberto Perez, Florian Hohla, Inwald, Elisabeth C, Perez, Roberto, Monika Klinkhammer-Schalke, Stefan Buchholz, Stephan Seitz, Ferenc G Rick, Szalontay, Luca, Florian Weber, Jörg Bernhard Engel, Seitz, Stephan, Chui Wai Kwok, Ortmann, Olaf, Segerer, Sabine, Sabine Segerer, Kwok, Chui Wai, Stephan Seitz, Luca Szalontay, Rick, Ferenc G.   +32 more
core   +1 more source

Targeted chemotherapy for triple-negative breast cancers via LHRH receptor [PDF]

, 2011
Triple-negative breast cancer does not express estrogen and progesterone receptors and there is no over-expression/amplification of the HER2-neu gene. Therefore, this subtype of breast cancer lacks the benefits of specific therapies which target these ...
Duwe, Francesca, Foest, Crispin, Hellriegel, Martin, Schweyer, Stefan, Emons, Guenter, Gruendker, Carsten   +5 more
core   +1 more source

Risk of hormone escape in a human prostate cancer model depends on therapy modalities and can be reduced by tyrosine kinase inhibitors.

PLoS ONE, 2012
Almost all prostate cancers respond to androgen deprivation treatment but many recur. We postulated that risk of hormone escape--frequency and delay--are influenced by hormone therapy modalities.
Charlotte Guyader, Jocelyn Céraline, Eléonore Gravier, Aurélie Morin, Sandrine Michel, Eva Erdmann, Gonzague de Pinieux, Florence Cabon, Jean-Pierre Bergerat, Marie-France Poupon, Stéphane Oudard   +10 more
doaj   +1 more source

Single‐nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Gonadotropin‐releasing hormone (GnRH) is a central regulator of vertebrate reproduction regulating pituitary gonadotropins. In zebrafish, GnRH3 serves as the hypophysiotropic isoform. Its neurons develop by migrating from the nasal placode to the hypothalamus, forming several distinct subpopulations along the migratory path.
Yalong Sun, Matan Golan, Yonathan Zohar, Xiaoxuan Fan, Nilli Zmora   +4 more
wiley   +1 more source

Discovery of LHRH and development of LHRH analogs for prostate cancer treatment [PDF]

, 2017
The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone‐releasing hormone (LHRH), which regulates reproduction, is briefly described.
Block, Norman L, Ferenc G. Rick, Schally, Andrew V, Andrew V. Schally, Rick, Ferenc G, Norman L. Block   +5 more
core   +1 more source

Changes in pituitary and ovarian LHRH receptors after active immunization of female rats against LH or LHRH [PDF]

Reproduction, 1985
Summary. The hypothalamic—pituitary—ovarian axis of female rats was disrupted at the site of LHRH stimulation by active immunization against LHRH or at the site of LH action by active immunization against LH. Active immunization against LH was associated with an increase in pituitary LHRH receptors to levels comparable to control ...
R M, Popkin, H M, Fraser
openaire   +2 more sources

Impact of Intraprostatic Simultaneous Integrated Boost on Long‐Term Outcomes in Unfavorable Intermediate‐Risk Prostate Cancer Treated With Dose‐Escalated Radiotherapy and Short‐Term Androgen Deprivation Therapy

The Prostate, Volume 86, Issue 8, Page 961-969, June 2026.
ABSTRACT Background Unfavorable intermediate‐risk prostate cancer (UIR‐PCa) represents a biologically heterogeneous subgroup with a higher risk of recurrence compared with favorable intermediate‐risk disease. Contemporary management frequently includes dose‐escalated radiotherapy (RT) combined with short‐term androgen deprivation therapy (ADT). Whether
Cem Onal, Aysenur Elmali, Birhan Demirhan, Ertugrul Senturk, Petek Erpolat, Ozan Cem Guler   +5 more
wiley   +1 more source

Castration Resistance Accelerates Prostate Cancer Kinetics

The Prostate, Volume 86, Issue 9, Page 1021-1027, June 15, 2026.
ABSTRACT Background Prostate cancer can be an indolent disease with which patients can live for many years. Thus, an understanding of how therapy and its ensuing resistance affect prostate cancer kinetics may guide efforts to determine optimal timing of therapy initiation.
Sheila Jonnatan, Luka Cavka, Angelo M. De Marzo, Samuel R. Denmeade, Mark C. Markowski, Emmanuel S. Antonarakis, Bruce J. Trock, Catherine H. Marshall, Ravi A. Madan, David J. Einstein, Laura A. Sena   +10 more
wiley   +1 more source