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Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta
Current Opinion in Endocrinology, Diabetes & Obesity, 2011This review summarizes our current understanding of the role of gonadotropin-releasing hormone (GnRH)/GnRH receptor (GnRHR) signaling at the maternal-fetal interface.Several isoforms of GnRH and GnRHR are described. The hypothalamic decapeptide, GnRH-I, binds to the anterior pituitary and induces the synthesis and secretion of luteinizing hormone and ...
Kirsten, Sasaki, Errol R, Norwitz
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Evolution of gonadotropin-releasing hormones
Trends in Endocrinology & Metabolism, 1992GnRH was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, multiple molecular forms of the peptide have evolved, which have been coopted for a variety of regulatory functions: as a neurotransmitter in the central and sympathetic ...
J A, King, R P, Millar
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Gonadotropin-Releasing Hormone in the Ovary
Reproductive Sciences, 2007Gonadotropin-releasing hormone (GnRH) plays a pivotal role in the physiology of reproduction in mammals. GnRH acts by binding to the GnRH receptor (GnRHR). In humans, only 1 conventional GnRH receptor subtype (type I GnRH receptor) has been found. In the human genome, 2 forms of GnRH have been identified, GnRH-I (mammal GnRH) and GnRH-II (chicken GnRH ...
Chryssa, Metallinou +3 more
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Clinical applications of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs
Fertility and Sterility, 1983Investigations have proved the clinical importance of hypothalmic gonadotropin-releasing hormone (GnRH) and its agonistic and antagonistic analogs. A pulsatile pattern of stimulation of specific receptors in the anterior pituitary gonadotrope has been shown to activate pituitary-gonadal function; continuous administration inhibits it.
Edward E. Wallach, Samuel S.C. Yen
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Conformation of gonadotropin releasing hormone
Biochemistry, 1976The conformation of the gonadotropin releasing hormone (Gn-RH), whose primary sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2, and of several of its structural analogues has been studied by circular dichroism, optical rotatory dispersion, and fluorescence spectroscopy.
S, Mabrey, I M, Klotz
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GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS
Annual Review of Medicine, 1991▪ Abstract GnRH and its analogues have led to exciting new avenues of therapy in virtually every subspecialty of internal medicine as well as in gynecology, pediatrics, and urology. Since their discovery in 1971, it has been demonstrated that GnRH and its analogues enable medical professionals to influence the hypothalamic-pituitary-gonadal axis in ...
Jane F. Desforges +2 more
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Gonadotropin-Releasing Hormone
Annual Review of Medicine, 1975The existence of a hypothalamic gonadotropin-releasing hormone long suspected from indirect evidence (1) has now been conclusively proven. In 1971, the primary structure of porcine (2) and subsequently ovine (3) luteinizing hormone-releasing hormone or factor (LRH or LRF) was determined to be the decapeptide pGlu-His Trp-Ser-Tyr-Gly-Leu-Arg-pro-Gly ...
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