Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study. [PDF]
BMC Med, 2023 Li X +8 more
europepmc +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.Evidence‐informed recommendations emphasize the integration of CDK4/6 inhibitors with endocrine therapy as a central component in the management of HR+/HER2− advanced breast cancer in Indonesia. Expanding access and facilitating integration within national treatment frameworks are crucial to improve outcomes and reduce disparities in care.
Sonar Soni Panigoro +9 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Diabetes mellitus (DM) induces multifaceted cellular and structural alterations in the male reproductive system, thereby predisposing to infertility. Objectives This study aimed to evaluate the morphological, stereological, biochemical, histopathological, and ultrastructural changes induced by DM in testicular tissue, and to ...
Ayşenur Kaya Mutlu, Süleyman Kaplan
wiley +1 more source
Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice. [PDF]
Elife, 2021 Toufaily C +16 more
europepmc +1 more source
Andrology, EarlyView.ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni +16 more
wiley +1 more source
Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes. [PDF]
Mol Cell Endocrinol, 2021 Ryan GE +7 more
europepmc +1 more source
Andrology, EarlyView.ABSTRACT Background Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. Objectives The objective is to map these sources and define what each can support when counseling men receiving metabolic drugs ...
Marek Broul +3 more
wiley +1 more source
Therapeutic effects of an oral gonadotropin-releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF. [PDF]
Reprod Med Biol, 2022 Nakao K +10 more
europepmc +1 more source
The contribution of His7.36(305) of the GnRH receptor to ligand binding and receptor activation [PDF]
, 2004 Bibliography: leaves 88-104.The current study was perfonned to give insights into the role of individual amino acid residues of both the GnRH receptor and the GnRH ligand in receptor function.
Mayevu, Ntateko Merriam Immogen
core +1 more source
The Impact of Common Medications on Male Fertility: An Updated Systematic Review
Andrology, EarlyView.ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli +7 more
wiley +1 more source