Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]
, 2012 Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques +12 more
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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line [PDF]
, 2010 Includes abstract.Includes bibliographical references (leaves 121-158).A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone ...
Wehmeyer, Lance
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Cloning and characterisation of gonadotropin-releasing hormone (GnRH) receptors in the cichlid (Haplochromis burtoni) and the zebrafish (Danio rerio) [PDF]
, 2003 Bibliography: leaves 75-89.The identification of multiple forms of gonadotropin-releasing hormone (GnRH) in a single species is becoming a common occurrence.
Morley, Michelle Gaye
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Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding
Frontiers in Endocrinology, 2017 Gonadotropin-releasing hormone (GnRH) regulates reproduction. The human GnRH receptor lacks a cytoplasmic carboxy-terminal tail but has amino acid sequence motifs characteristic of rhodopsin-like, class A, G protein-coupled receptors (GPCRs). This review
Colleen A. Flanagan, Ashmeetha Manilall
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Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor [PDF]
Fertility and Sterility, 2007 To determine the presence or absence of a second form of GnRH (GnRH2) and corresponding receptor (GnRHR2) in human uterine myometrium and leiomyomata.Evaluation of human leiomyoma and patient-matched myometrium of differential mRNA and protein expression of GnRH2 and GnRHR2.University hospital.Eight women undergoing medically indicated hysterectomy for
Parker, Jason D. +2 more
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Structure and function of sea urchin neuropeptides [PDF]
, 2010 PhDThe subject of this thesis is the identification and functional characterization of sea urchin neuropeptides. Neuropeptides are important mediators of neural signalling in all known animals with a nervous system, including bilaterians, ctenophorans ...
Rowe, Matthew Lyndon
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor [PDF]
, 2008 Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
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Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure
BiomedicinesSeveral reproductive issues in both men and women are caused by changes in the pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Athanasios Zikopoulos +9 more
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Effect of gonadotropin-releasing hormone agonist on ES-2 ovarian cancer cells
Taiwanese Journal of Obstetrics & Gynecology, 2014 Objective: Gonadotropin-releasing hormone (GnRH) receptor is found in the ovarian tissue, including epithelial ovarian cancer (EOC), suggesting that GnRH agonists may have direct action on EOC.
Kuan-Hao Tsui +9 more
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Identification and Characterization of the Gonadotropin-releasing Hormone Response Elements in the Mouse Gonadotropin-releasing Hormone Receptor Gene [PDF]
Journal of Biological Chemistry, 1999 The response of the pituitary gonadotrope to gonadotropin-releasing hormone (GnRH) correlates directly with the concentration of GnRH receptors (GnRHR) on the cell surface, which is mediated in part at the level of GnRHR gene expression. Several hormones have been implicated in this regulation, most notably GnRH itself.
E R, Norwitz +3 more
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