Results 71 to 80 of about 7,257,092 (316)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
expediency and corruption and good and bad; unity or contrast [PDF]
اخلاق وحیانیExpediency and corruption in the term is the base of legislating Sharia rules. On the other hand, beauty and ugliness are concepts that have a long history in various sciences, and different meanings such as perfection and imperfection, agreement and ...
Mohammadhasan Samooei +1 more
doaj +1 more source
When are Goods More Goods? [PDF]
Economica, 1958 It is here implied that if A is chosen rather than B, A represents more (or not fewer) goods than B (even if A contains less of some individual goods). This sounds rather like the converse of the axiom of nonsaturation, which states that if A contains more goods than B in the vector sense (i.e. more of some goods and less of none) then A will be chosen
openaire +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
BASIC MORAL STANDARDS IN ETIC SYSTEM OF I. KANT
Дискурс, 2017 The article reviews main items of I. Kant ethical system based on I. Kant work “Critique of Pure Reason”, “Groundwork of the Metaphysics of Morals”, “Prolegomena to Any Future Metaphysics”. The article analyzes the main issues of I. Kant philosophy: will
A. M. Sklyarovа
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
De dysenteriae curatione & praeservatione
quam ... ad diem 6. Decembris, M D CC XLIII. pro summis in medicina honoribus & privilegiis doctoralibus rite capessendis eruditorum examini submittit Bonifacius Iosephus Antonius Good, Ragazensis HelvetusDiss. med.
Good, Bonifacius Josephus Antonius
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source